ChEMBL ligand: CHEMBL4238186
H-PGDS/Hematopoietic prostaglandin D synthase in Human [ChEMBL: CHEMBL5879] [GtoPdb: 1381] [UniProtKB: O60760] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
H-PGDS/Hematopoietic prostaglandin D synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5879] [GtoPdb: 1381] [UniProtKB: O60760]
ChEMBL	Binding affinity to full length recombinant human N-terminal His6-tagged H-PGDS expressed in Escherichia coli BL21(DE3) by SPR analysis	B	9.43	pKd	0.37	nM	Kd	Bioorg Med Chem (2018) 26: 4726-4734 [PMID:30121213]
ChEMBL	Binding affinity to recombinant human HPGDS expressed in Escherichia coli BL21 (DE3) measured after 1 hr by fluorescence polarization assay	B	6.49	pIC50	320	nM	IC50	ACS Med Chem Lett (2021) 12: 236-241 [PMID:33603969]
ChEMBL	Binding affinity to recombinant human H-PGDS incubated for 1 hrs by competitive fluorescence polarization assay	B	6.68	pIC50	211.2	nM	IC50	RSC Med Chem (2022) 13: 1495-1503 [PMID:36561070]
ChEMBL	Inhibition of H-PGDS (unknown origin) using fluorescent probe by competition binding assay	B	6.77	pIC50	170	nM	IC50	J Med Chem (2021) 64: 15868-15882 [PMID:34652145]
GtoPdb	-	-	7.08	pIC50	-	-	-	Prostaglandins Other Lipid Mediat (2011) 95: 27-34 [PMID:21601002]
ChEMBL	Inhibition of recombinant human HPGDS using [14C]-PGH2 as substrate preincubated for 1 min in presence of MgCl2 followed by substrate addition and measured after 45 mins by radioactive imaging analysis	B	7.08	pIC50	83	nM	IC50	ACS Med Chem Lett (2021) 12: 236-241 [PMID:33603969]
ChEMBL	Inhibition of recombinant human HPGDS expressed in Escherichia coli BL21 (DE3) measured after 3 mins by spectrophotometric analysis	B	7.15	pIC50	71	nM	IC50	ACS Med Chem Lett (2021) 12: 236-241 [PMID:33603969]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]