ChEMBL ligand: CHEMBL274990 (SC-58125)
COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] Cyclooxygenase-1 in Sheep [ChEMBL: CHEMBL2949] [UniProtKB: P05979] There should be some charts here, you may need to enable JavaScript!
COX-2 /Cyclooxygenase-2 in Human [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] COX-2 /Cyclooxygenase-2 in Mouse [ChEMBL: CHEMBL4321] [GtoPdb: 1376] [UniProtKB: Q05769] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL	Inhibition of human Prostaglandin G/H synthase 1 at 10 ug/mL expressed as the mean percent inhibition of control PGE-2 production	B	4	pIC50	>100000	nM	IC50	J Med Chem (1997) 40: 980-989 [PMID:9083488]
ChEMBL	In vitro inhibition of prostaglandin G/H synthase 1.	B	4	pIC50	>100000	nM	IC50	J Med Chem (1995) 38: 4570-4578 [PMID:7473585]
ChEMBL	Tested for inhibition against Prostaglandin G/H synthase 1	B	4	pIC50	>100000	nM	IC50	J Med Chem (1994) 37: 3878-3881 [PMID:7966148]
ChEMBL	In vitro inhibitory concentration against recombinant human COX-1 (Cyclooxygenase-1)	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem Lett (1997) 7: 2121-2124
ChEMBL	Inhibitory activity against human recombinant Prostaglandin G/H synthase 1 expressed in microsomes taken from baculovirus infected Sf9 cells	B	4.3	pIC50	>50000	nM	IC50	Bioorg Med Chem Lett (1996) 6: 87-92
ChEMBL	Inhibition of human COX1 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassay	B	4.49	pIC50	32000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4509-4514 [PMID:19523822]
ChEMBL	IC50 value against Prostaglandin G/H synthase 1 of human platelet rich plasma	B	4.7	pIC50	>20000	nM	IC50	J Med Chem (1999) 42: 1161-1169 [PMID:10197960]
ChEMBL	IC50 against Prostaglandin G/H synthase 1 from human platelet rich plasma	B	4.7	pIC50	>20000	nM	IC50	J Med Chem (1999) 42: 1151-1160 [PMID:10197959]
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL	IC50 value against ovine Prostaglandin G/H synthase 1	B	4.7	pIC50	>20000	nM	IC50	J Med Chem (1999) 42: 1161-1169 [PMID:10197960]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL	Inhibition of COX-2 (unknown origin)	B	5.96	pIC50	1100	nM	IC50	Bioorg Med Chem Lett (2016) 26: 1516-1520 [PMID:26898334]
ChEMBL	IC50 against recombinant human Prostaglandin G/H synthase 2	B	6.51	pIC50	310	nM	IC50	J Med Chem (1999) 42: 1151-1160 [PMID:10197959]
ChEMBL	Inhibition of recombinant human prostaglandin G/H synthase 2 (COX-2)	B	6.51	pIC50	310	nM	IC50	J Med Chem (1999) 42: 1161-1169 [PMID:10197960]
ChEMBL	Inhibitory activity against human recombinant Prostaglandin G/H synthase 2 expressed in microsomes taken from baculovirus infected Sf9 cells	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (1996) 6: 87-92
ChEMBL	Inhibition of human cyclooxygenase-2 (hCOX-2) enzyme.	B	7	pIC50	100	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1167-1170 [PMID:10328306]
ChEMBL	Inhibition of human Prostaglandin G/H synthase 2	B	7	pIC50	100	nM	IC50	J Med Chem (2001) 44: 3223-3230 [PMID:11563921]
ChEMBL	In vitro inhibitory concentration against human Prostaglandin G/H synthase 2	B	7	pIC50	100	nM	IC50	Bioorg Med Chem Lett (1997) 7: 2121-2124
ChEMBL	In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)	B	7	pIC50	100	nM	IC50	J Med Chem (1997) 40: 1347-1365 [PMID:9135032]
ChEMBL	Tested for inhibition against Prostaglandin G/H synthase 2	B	7.05	pIC50	90	nM	IC50	J Med Chem (1994) 37: 3878-3881 [PMID:7966148]
ChEMBL	Inhibition of human Prostaglandin G/H synthase 2 at 10 ug/mL expressed as the mean percent inhibition of control PGE-2 production	B	7.05	pIC50	90	nM	IC50	J Med Chem (1997) 40: 980-989 [PMID:9083488]
ChEMBL	Inhibition of human COX2 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassay	B	7.18	pIC50	66	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4509-4514 [PMID:19523822]
ChEMBL	In vitro inhibition of prostaglandin G/H synthase 2 (COX-2).	B	7.3	pIC50	50	nM	IC50	J Med Chem (1995) 38: 4570-4578 [PMID:7473585]
GtoPdb	-	-	7.39	pIC50	-	-	-	J Biol Chem (1996) 271: 15810-4 [PMID:8663121]
COX-2 /Cyclooxygenase-2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4321] [GtoPdb: 1376] [UniProtKB: Q05769]
ChEMBL	IC50 value was determined against Prostaglandin G/H synthase 2 of J7744A.1 cell lines.	B	7.15	pIC50	70	nM	IC50	J Med Chem (1999) 42: 1151-1160 [PMID:10197959]
ChEMBL	IC50 value against Prostaglandin G/H synthase 2 of murine J774A.1 cell line	B	7.15	pIC50	70	nM	IC50	J Med Chem (1999) 42: 1161-1169 [PMID:10197960]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]