ciclopirox [Ligand Id: 11349] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1413 (Ciclopirox, Cyclopirox, HOE 296B, HOE-296B, Loprox, Penlac)
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  • isocitrate dehydrogenase (NADP(+)) 1/Isocitrate dehydrogenase [NADP] cytoplasmic in Human [ChEMBL: CHEMBL2007625] [GtoPdb: 2884] [UniProtKB: O75874]
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  • lysine demethylase 4B/Lysine-specific demethylase 4B in Human [ChEMBL: CHEMBL3313832] [GtoPdb: 2676] [UniProtKB: O94953]
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  • poly(ADP-ribose) polymerase 1 in Human [GtoPdb: 2771] [UniProtKB: P09874]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Deoxyhypusine hydroxylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523441] [UniProtKB: Q9BU89]
ChEMBL Inhibition of DOHH (unknown origin) B 5.3 pIC50 5000 nM IC50 Eur J Med Chem (2019) 165: 172-197 [PMID:30684796]
isocitrate dehydrogenase (NADP(+)) 1/Isocitrate dehydrogenase [NADP] cytoplasmic in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007625] [GtoPdb: 2884] [UniProtKB: O75874]
ChEMBL Inhibition of human IDH1 R132H mutant expressed in Escherichia coli BL21-CodonPlus assessed as reduction in NADPH consumption B 4.3 pKi >50000 nM Ki J Med Chem (2014) 57: 8307-8318 [PMID:25271760]
lysine demethylase 4B/Lysine-specific demethylase 4B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3313832] [GtoPdb: 2676] [UniProtKB: O94953]
ChEMBL Inhibition of GST-tagged KDM4B (unknown origin) using H3K9(me3)-biotin peptide as substrate incubated for 30 mins and measured after 15 mins by TR-FRET assay B 5.42 pIC50 3800 nM IC50 J Med Chem (2022) 65: 9564-9579 [PMID:35838529]
poly(ADP-ribose) polymerase 1 in Human [GtoPdb: 2771] [UniProtKB: P09874]
GtoPdb - - 6.8 pIC50 160 nM IC50 Bioorg Med Chem Lett (2008) 18: 5126-9 [PMID:18713665]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]