ChEMBL ligand: CHEMBL4128069
unc-51 like autophagy activating kinase 1/Serine/threonine-protein kinase ULK1 in Human [ChEMBL: CHEMBL6006] [GtoPdb: 2271] [UniProtKB: O75385] There should be some charts here, you may need to enable JavaScript!
unc-51 like autophagy activating kinase 2/Serine/threonine-protein kinase ULK2 in Human [ChEMBL: CHEMBL5435] [GtoPdb: 2272] [UniProtKB: Q8IYT8] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
unc-51 like autophagy activating kinase 1/Serine/threonine-protein kinase ULK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6006] [GtoPdb: 2271] [UniProtKB: O75385]
ChEMBL	Inhibition of ULK1 (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRET assay	B	6.11	pIC50	785	nM	IC50	J Med Chem (2020) 63: 14609-14625 [PMID:33200929]
ChEMBL	Inhibition of recombinant human ULK1 (1-649) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay	B	6.89	pIC50	130	nM	IC50	J Med Chem (2020) 63: 14609-14625 [PMID:33200929]
GtoPdb	-	-	6.89	pIC50	130	nM	IC50	Mol Cell (2015) 59: 285-97 [PMID:26118643]
ChEMBL	Inhibition of GST-tagged ULK1 (unknown origin)	B	6.97	pIC50	108	nM	IC50	J Med Chem (2018) 61: 6491-6500 [PMID:29509411]
ChEMBL	Inhibition of FLAG-tagged ULK1 (unknown origin) expressed in HEK293T cells using GST-labelled Atg101 as substrate in presence of gamma-[32]P-ATP	B	6.97	pIC50	108	nM	IC50	J Med Chem (2018) 61: 4656-4687 [PMID:29211480]
ChEMBL	Inhibition of ULK1 (unknown origin) by 32P-ATP radio active assay	B	6.97	pIC50	108	nM	IC50	Eur J Med Chem (2020) 208: 112782-112782 [PMID:32961380]
ChEMBL	Competitive inhibition of ULK1 (unknown origin) in presence of ATP	B	6.97	pIC50	108	nM	IC50	Eur J Med Chem (2022) 244: 114846-114846 [PMID:36283182]
unc-51 like autophagy activating kinase 2/Serine/threonine-protein kinase ULK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5435] [GtoPdb: 2272] [UniProtKB: Q8IYT8]
ChEMBL	Inhibition of ULK2 (unknown origin) expressed in HEK293T cells incubated for 2 hrs by NanoBRET assay	B	5.34	pIC50	4578	nM	IC50	J Med Chem (2020) 63: 14609-14625 [PMID:33200929]
ChEMBL	Inhibition of recombinant human ULK2 (1 to 478 residues) expressed in Sf9 cells using myelin basic protein as substrate by ADP-glo assay	B	5.61	pIC50	2448	nM	IC50	J Med Chem (2020) 63: 14609-14625 [PMID:33200929]
ChEMBL	Inhibition of GST-tagged ULK2 (unknown origin)	B	6.15	pIC50	711	nM	IC50	J Med Chem (2018) 61: 6491-6500 [PMID:29509411]
ChEMBL	Inhibition of ULK2 (unknown origin)	B	6.15	pIC50	711	nM	IC50	Eur J Med Chem (2020) 208: 112782-112782 [PMID:32961380]
ChEMBL	Inhibition of ULK2 (unknown origin)	B	7.96	pIC50	11	nM	IC50	J Med Chem (2018) 61: 4656-4687 [PMID:29211480]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]