EG00229 [Ligand Id: 11335] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1078974 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| neuropilin 1/Neuropilin-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5174] [GtoPdb: 2998] [UniProtKB: O14786] | ||||||||
| ChEMBL | Displacement of biotinylated-VEGF-A125 from human NRP1 expressed in HUVEC | B | 4.64 | pIC50 | 23000 | nM | IC50 | J Med Chem (2010) 53: 2215-2226 [PMID:20151671] |
| ChEMBL | Inhibition of recombinant human biotinylated VEGF-165A expressed in HEK293 cells binding to immobilized recombinant full length human FC-tagged NRP1 (chimera active) expressed in HEK293 cells using TMB as substrate incubated for 2 hrs followed by substrate addition by competitive ELISA | B | 4.95 | pIC50 | 11100 | nM | IC50 | Bioorg Med Chem (2020) 28: 115183-115183 [PMID:31744780] |
| GtoPdb | Inhibition of binding between 125I-VEGF-A165 to NRP1 in a cellular assay. | - | 5.05 | pIC50 | 9000 | nM | IC50 | J Med Chem (2010) 53: 2215-26 [PMID:20151671] |
| ChEMBL | Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells | B | 5.1 | pIC50 | 8000 | nM | IC50 | J Med Chem (2010) 53: 2215-2226 [PMID:20151671] |
| ChEMBL | Displacement of [125I]VEGF-A from human NRP1 expressed in human A549 cells | B | 5.15 | pIC50 | 7000 | nM | IC50 | J Med Chem (2010) 53: 2215-2226 [PMID:20151671] |
| ChEMBL | Displacement of biotinylated-VEGF-A125 from NRP1 b1 domain by cell-free assay | B | 5.52 | pIC50 | 3000 | nM | IC50 | J Med Chem (2010) 53: 2215-2226 [PMID:20151671] |
| ChEMBL | Displacement of biotinylated-VEGF-A125 from human NRP1 expressed in human DU145 cells | B | 5.52 | pIC50 | 3000 | nM | IC50 | J Med Chem (2010) 53: 2215-2226 [PMID:20151671] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
