EG00229 [Ligand Id: 11335] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1078974 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Guanylyl cyclase-A/Atrial natriuretic peptide receptor A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1988] [GtoPdb: 1747] [UniProtKB: P16066] | ||||||||
| ChEMBL | Inhibition of [125I]-VEGF-A165 binding to NPR1 (unknown origin) transfected in HUVECs incubated for 2 hrs by plate reader analysis | B | 5.54 | pIC50 | 2910 | nM | IC50 | J Med Chem (2023) 66: 16187-16200 [PMID:38093696] |
| neuropilin 1/Neuropilin-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5174] [GtoPdb: 2998] [UniProtKB: O14786] | ||||||||
| ChEMBL | Displacement of biotinylated-VEGF-A125 from human NRP1 expressed in HUVEC | B | 4.64 | pIC50 | 23000 | nM | IC50 | J Med Chem (2010) 53: 2215-2226 [PMID:20151671] |
| ChEMBL | Inhibition of recombinant human biotinylated VEGF-165A expressed in HEK293 cells binding to immobilized recombinant full length human FC-tagged NRP1 (chimera active) expressed in HEK293 cells using TMB as substrate incubated for 2 hrs followed by substrate addition by competitive ELISA | B | 4.95 | pIC50 | 11100 | nM | IC50 | Bioorg Med Chem (2020) 28: 115183-115183 [PMID:31744780] |
| GtoPdb | Inhibition of binding between 125I-VEGF-A165 to NRP1 in a cellular assay. | - | 5.05 | pIC50 | 9000 | nM | IC50 | J Med Chem (2010) 53: 2215-26 [PMID:20151671] |
| ChEMBL | Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells | B | 5.1 | pIC50 | 8000 | nM | IC50 | J Med Chem (2010) 53: 2215-2226 [PMID:20151671] |
| ChEMBL | Displacement of [125I]VEGF-A from human NRP1 expressed in human A549 cells | B | 5.15 | pIC50 | 7000 | nM | IC50 | J Med Chem (2010) 53: 2215-2226 [PMID:20151671] |
| ChEMBL | Displacement of biotinylated-VEGF-A125 from NRP1 b1 domain by cell-free assay | B | 5.52 | pIC50 | 3000 | nM | IC50 | J Med Chem (2010) 53: 2215-2226 [PMID:20151671] |
| ChEMBL | Displacement of biotinylated-VEGF-A125 from human NRP1 expressed in human DU145 cells | B | 5.52 | pIC50 | 3000 | nM | IC50 | J Med Chem (2010) 53: 2215-2226 [PMID:20151671] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
