ChEMBL ligand: CHEMBL3941880
FFA1 receptor/Free fatty acid receptor 1 in Human [ChEMBL: CHEMBL4422] [GtoPdb: 225] [UniProtKB: O14842] There should be some charts here, you may need to enable JavaScript!
FFA4 receptor/G-protein coupled receptor 120 in Human [ChEMBL: CHEMBL5339] [GtoPdb: 127] [UniProtKB: Q5NUL3] FFA4 receptor in Mouse [GtoPdb: 127] [UniProtKB: Q7TMA4] There should be some charts here, you may need to enable JavaScript!
FFA4 receptor in Human [GtoPdb: 127] [UniProtKB: Q5NUL3] FFA4 receptor/Omega-3 fatty acid receptor 1 in Mouse [ChEMBL: CHEMBL2052036] [GtoPdb: 127] [UniProtKB: Q7TMA4] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
FFA1 receptor/Free fatty acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4422] [GtoPdb: 225] [UniProtKB: O14842]
ChEMBL	Antagonist activity against human FFA1 expressed in human Flp-In T-REx293 cells assessed as as reduction in TUG424-induced response by Fura2-AM dye based calcium mobilization assay	F	4	pIC50	>100000	nM	IC50	J Med Chem (2016) 59: 8868-8878 [PMID:27570890]
FFA4 receptor/G-protein coupled receptor 120 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5339] [GtoPdb: 127] [UniProtKB: Q5NUL3]
GtoPdb	Determined in a Ca2+ mobilization assay.	-	6.63	pEC50	234	nM	EC50	J Med Chem (2016) 59: 8868-8878 [PMID:27570890]
ChEMBL	Agonist activity at human FFA4 expressed in human Flp-In T-REx293 cells by Fura2-AM dye based calcium mobilization assay	F	6.63	pEC50	234.42	nM	EC50	J Med Chem (2016) 59: 8868-8878 [PMID:27570890]
ChEMBL	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	B	6.89	pEC50	128	nM	EC50	J Med Chem (2016) 59: 8868-8878 [PMID:27570890]
ChEMBL	Agonist activity at C-terminal YFP-tagged human FFA4 expressed in HEK293 cells in presence of coelentrazine h by BRET based beta-arrestin-2 interaction assay	B	6.91	pEC50	123.03	nM	EC50	J Med Chem (2016) 59: 8868-8878 [PMID:27570890]
FFA4 receptor in Mouse [GtoPdb: 127] [UniProtKB: Q7TMA4]
GtoPdb	Determined in a Ca2+ mobilization assay.	-	6.83	pEC50	148	nM	EC50	J Med Chem (2016) 59: 8868-8878 [PMID:27570890]
FFA4 receptor in Human [GtoPdb: 127] [UniProtKB: Q5NUL3]
GtoPdb	Determined in a Ca2+ mobilization assay.	-	6.63	pEC50	234	nM	EC50	J Med Chem (2016) 59: 8868-8878 [PMID:27570890]
FFA4 receptor/Omega-3 fatty acid receptor 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2052036] [GtoPdb: 127] [UniProtKB: Q7TMA4]
ChEMBL	Agonist activity mouse FFA4 by by BRET based beta-arrestin-2 interaction assay	B	6.32	pEC50	478.63	nM	EC50	J Med Chem (2016) 59: 8868-8878 [PMID:27570890]
GtoPdb	Determined in a Ca2+ mobilization assay.	-	6.83	pEC50	148	nM	EC50	J Med Chem (2016) 59: 8868-8878 [PMID:27570890]
ChEMBL	Agonist activity mouse FFA4 by Gq-dependent calcium mobilization assay	F	6.83	pEC50	147.91	nM	EC50	J Med Chem (2016) 59: 8868-8878 [PMID:27570890]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]