ETC-1922159 [Ligand Id: 11168] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3633802 (Etc-159, Etc-1922159) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| porcupine O-acyltransferase/Probable protein-cysteine N-palmitoyltransferase porcupine in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1255163] [GtoPdb: 3145] [UniProtKB: Q9H237] | ||||||||
| ChEMBL | Inhibition of porcupine in human HEK293 cells assessed as reduction in Wnt secretion by measuring suppression of beta-catenin reporter activity after 24 hrs by STF reporter assay | B | 8.54 | pIC50 | 2.9 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 5472-5476 [PMID:26522946] |
| ChEMBL | Inhibition of porcupine (unknown origin) | B | 8.54 | pIC50 | 2.9 | nM | IC50 | J Med Chem (2017) 60: 6678-6692 [PMID:28671458] |
| GtoPdb | - | - | 8.54 | pIC50 | 2.9 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 5472-6 [PMID:26522946] |
| porcupine O-acyltransferase/Probable protein-cysteine N-palmitoyltransferase porcupine in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1255164] [GtoPdb: 3145] [UniProtKB: Q9JJJ7] | ||||||||
| ChEMBL | Inhibition of mouse porcupine expressed in human HT1080 cells assessed as reduction in beta catenin reporter activity using firefly luciferase substrate STF reporter assay | B | 7.74 | pIC50 | 18.1 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 5472-5476 [PMID:26522946] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
