GSK1795091 [Ligand Id: 11150] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL507938 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TLR4/Toll-like receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5255] [GtoPdb: 1754] [UniProtKB: O00206] | ||||||||
| ChEMBL | Agonist activity at human TLR4 in human HEK-Blue hTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti-blue assay | B | 9.03 | pEC50 | 0.93 | nM | EC50 | J Med Chem (2023) 66: 13900-13917 [PMID:37847244] |
| ChEMBL | Agonist activity at TLR4 in human PBMC cells assessed as induction of TNFalpha release incubated for 20 hrs by ELISA | B | 9.59 | pEC50 | 0.26 | nM | EC50 | J Med Chem (2023) 66: 13900-13917 [PMID:37847244] |
| GtoPdb | Determined by measuring induction of TNFα production in primary human monocytes. | - | 9.77 | pEC50 | 0.17 | nM | EC50 | Bioorg Med Chem Lett (2008) 18: 5350-4 [PMID:18835160] |
| ChEMBL | Agonist activity at TLR4 in human MONO-MAC-6 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISA | B | 10.22 | pEC50 | 0.06 | nM | EC50 | J Med Chem (2023) 66: 13900-13917 [PMID:37847244] |
| ChEMBL | Agonist activity at TLR4 in human PBMC cells assessed as induction of IL-1beta release incubated for 20 hrs by ELISA | B | 10.55 | pEC50 | 0.03 | nM | EC50 | J Med Chem (2023) 66: 13900-13917 [PMID:37847244] |
| ChEMBL | Agonist activity at TLR4 in human PBMC cells assessed as induction of RANTES release incubated for 20 hrs by ELISA | B | 10.85 | pEC50 | 0.01 | nM | EC50 | J Med Chem (2023) 66: 13900-13917 [PMID:37847244] |
| ChEMBL | Agonist activity at TLR4 in human PBMC cells assessed as induction of MIP-1beta release incubated for 20 hrs by ELISA | B | 11 | pEC50 | 0.01 | nM | EC50 | J Med Chem (2023) 66: 13900-13917 [PMID:37847244] |
| TLR4/Toll-like receptor 4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795167] [GtoPdb: 1754] [UniProtKB: Q9QUK6] | ||||||||
| ChEMBL | Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISA | B | 10.82 | pEC50 | 0.01 | nM | EC50 | J Med Chem (2023) 66: 13900-13917 [PMID:37847244] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
