bavarostat [Ligand Id: 11119] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4165724 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] | ||||||||
| ChEMBL | Inhibition of human recombinant HDAC1 using fluorogenic HDAC substrate by fluorescence assay | B | 6 | pIC50 | >1000 | nM | IC50 | J Med Chem (2019) 62: 8557-8577 [PMID:31414801] |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 6 | pIC50 | >1000 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 6 | pIC50 | >1000 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| histone deacetylase 11/Histone deacetylase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3310] [GtoPdb: 2615] [UniProtKB: Q96DB2] | ||||||||
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 5 | pIC50 | 10000 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 5 | pIC50 | 10000 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 5 | pIC50 | 10000 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] | ||||||||
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 6 | pIC50 | >1000 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 6 | pIC50 | >1000 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379] | ||||||||
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 6 | pIC50 | >1000 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 6 | pIC50 | >1000 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| histone deacetylase 4/Histone deacetylase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524] | ||||||||
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 4.95 | pIC50 | 11300 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 4.95 | pIC50 | 11300 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 8.15 | pIC50 | 7.1 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| histone deacetylase 5/Histone deacetylase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2563] [GtoPdb: 2660] [UniProtKB: Q9UQL6] | ||||||||
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 4.72 | pIC50 | 19000 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 4.72 | pIC50 | 19000 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 4.72 | pIC50 | 19000 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| GtoPdb | - | - | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2018) 61: 8054-8060 [PMID:30118224] |
| ChEMBL | Inhibition of human recombinant HDAC6 incubated for 90 mins using fluorogenic substrate ZMAL (Z-Lys(Ac)-AMC) by fluorescence based assay | B | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2018) 61: 8054-8060 [PMID:30118224] |
| ChEMBL | Inhibition of human recombinant HDAC6 using fluorogenic HDAC substrate by fluorescence assay | B | 7.22 | pIC50 | 60 | nM | IC50 | J Med Chem (2019) 62: 8557-8577 [PMID:31414801] |
| ChEMBL | Inhibition of human HDAC6 | B | 7.22 | pIC50 | 60 | nM | IC50 | Eur J Med Chem (2021) 209: 112887-112887 [PMID:33035922] |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 7.22 | pIC50 | 60 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 7.22 | pIC50 | 60 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 7.22 | pIC50 | 60 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 7.8 | pIC50 | 16 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| histone deacetylase 7/Histone deacetylase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2716] [GtoPdb: 2661] [UniProtKB: Q8WUI4] | ||||||||
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 5.33 | pIC50 | 4700 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 5.33 | pIC50 | 4700 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 5.33 | pIC50 | 4700 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41] | ||||||||
| ChEMBL | Inhibition of human HDAC8 | B | 5.07 | pIC50 | 8500 | nM | IC50 | Eur J Med Chem (2021) 209: 112887-112887 [PMID:33035922] |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 5.07 | pIC50 | 8500 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 5.07 | pIC50 | 8500 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 5.07 | pIC50 | 8500 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| histone deacetylase 9/Histone deacetylase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4145] [GtoPdb: 2620] [UniProtKB: Q9UKV0] | ||||||||
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 5.28 | pIC50 | 5200 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 5.28 | pIC50 | 5200 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 5.28 | pIC50 | 5200 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| histone deacetylase 10/Polyamine deacetylase HDAC10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8] | ||||||||
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 6 | pIC50 | >1000 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
| ChEMBL | IC50 Assay: IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. | B | 6 | pIC50 | >1000 | nM | IC50 | US-11207431-B2. HDAC6 inhibitors and imaging agents (2021) |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
