ChEMBL ligand: CHEMBL572 (Berkfurin, Ceduran, Dantafur, Furadantin, Furalan, Genfura, Ivadantin, Macrobid, Macrodantin, Nitrofurantoin, Nitrofurantoina, Nitrofurantoin anhydrous, Nitrofurantoine, Nitrofurantoin macrocrystal, Nitrofurantoin macrocrystalline, Nitrofurantoin, macrocrystalline, Nitrofurantoin, macrocrystals, Nitrofurantoin (monohydrate/macrocrystals), Nitrofurantoinum anhydrous, NSC-2107, NSC-44150)
CDGSH iron-sulfur domain-containing protein 1 in Human [ChEMBL: CHEMBL1795168] [UniProtKB: Q9NZ45] There should be some charts here, you may need to enable JavaScript!
GroEL/GroES in Escherichia coli [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1, Q7BGE6] There should be some charts here, you may need to enable JavaScript!
mitochondrial pyruvate carrier 2 in Human [GtoPdb: 3023] [UniProtKB: O95563] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CDGSH iron-sulfur domain-containing protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795168] [UniProtKB: Q9NZ45]
ChEMBL	Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by Cheng-Prusoff analysis	B	6.09	pKi	816	nM	Ki	Bioorg Med Chem Lett (2016) 26: 5350-5353 [PMID:27687671]
ChEMBL	Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by scintillation proximity assay	B	4.72	pIC50	19100	nM	IC50	Bioorg Med Chem Lett (2016) 26: 5350-5353 [PMID:27687671]
GroEL/GroES in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1, Q7BGE6]
ChEMBL	Inhibition of Escherichia coli GroEL/ES-mediated refolding of the denatured malate dehydrogenase	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem (2020) 28: 115710-115710 [PMID:33007545]
ChEMBL	Inhibition of Escherichia coli GroEL/ES-mediated refolding of the denatured malate dehydrogenase in presence of Escherichia coli type 1 NfsB nitroreductase	B	4.08	pIC50	84000	nM	IC50	Bioorg Med Chem (2020) 28: 115710-115710 [PMID:33007545]
ChEMBL	Inhibition of Escherichia coli GroEL/ES assessed as inhibition of native malate dehydrogenase treated after denatured malate dehydrogenase completely refold	B	4.2	pIC50	>63000	nM	IC50	Bioorg Med Chem (2020) 28: 115710-115710 [PMID:33007545]
ChEMBL	Inhibition of Escherichia coli GroEL/ES assessed as inhibition of native malate dehydrogenase treated after denatured malate dehydrogenase completely refold in presence of NfsB nitroreductase	B	4.25	pIC50	>56000	nM	IC50	Bioorg Med Chem (2020) 28: 115710-115710 [PMID:33007545]
mitochondrial pyruvate carrier 2 in Human [GtoPdb: 3023] [UniProtKB: O95563]
GtoPdb	-	-	5.48	pIC50	3300	nM	IC50	Mol Metab (2022) 60: 101469 [PMID:35278701]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]