(R)-ND-336 [Ligand Id: 10887] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4300809
  • MMP2 in Human [GtoPdb: 1629] [UniProtKB: P08253]
Created with Highcharts 10.3.3ValuesChart context menuMMP2pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • MMP9 in Human [GtoPdb: 1633] [UniProtKB: P14780]
Created with Highcharts 10.3.3ValuesChart context menuMMP9pKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • MMP14 in Human [GtoPdb: 1638] [UniProtKB: P50281]
Created with Highcharts 10.3.3ValuesChart context menuMMP14pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
MMP2 in Human [GtoPdb: 1629] [UniProtKB: P08253]
GtoPdb - - 6.9 pKi 127 nM Ki J Med Chem (2018) 61: 8825-8837 [PMID:30212201]
MMP9 in Human [GtoPdb: 1633] [UniProtKB: P14780]
GtoPdb - - 7.72 pKi 19 nM Ki J Med Chem (2018) 61: 8825-8837 [PMID:30212201]
MMP14 in Human [GtoPdb: 1638] [UniProtKB: P50281]
GtoPdb - - 6.92 pKi 119 nM Ki J Med Chem (2018) 61: 8825-8837 [PMID:30212201]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]