ChEMBL ligand: CHEMBL304087 (Merimepodib, VI-21,497, VI-21497, VX-497)
inosine monophosphate dehydrogenase 2/Inosine-5`-monophosphate dehydrogenase 2 in Human [ChEMBL: CHEMBL2002] [GtoPdb: 2625] [UniProtKB: P12268] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
inosine monophosphate dehydrogenase 2/Inosine-5`-monophosphate dehydrogenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2002] [GtoPdb: 2625] [UniProtKB: P12268]
ChEMBL	Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzyme	B	7.96	pIC50	11	nM	IC50	Bioorg Med Chem Lett (2003) 13: 3557-3560 [PMID:14505670]
GtoPdb	-	-	8	pIC50	10	nM	IC50	J Med Chem (2002) 45: 2127-30 [PMID:12014950]
ChEMBL	Inhibition of human inosine-5'-monophosphate dehydrogenase 2	B	8	pIC50	10	nM	IC50	J Med Chem (2002) 45: 2127-2130 [PMID:12014950]
ChEMBL	Inhibitory activity against inosine monophosphate dehydrogenase IMPDH II	B	8	pIC50	10	nM	IC50	Bioorg Med Chem Lett (2003) 13: 547-551 [PMID:12565969]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]