merimepodib [Ligand Id: 10741] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL304087 (Merimepodib, VI-21,497, VI-21497, VX-497) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| inosine monophosphate dehydrogenase 2/Inosine-5`-monophosphate dehydrogenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2002] [GtoPdb: 2625] [UniProtKB: P12268] | ||||||||
| ChEMBL | Inhibitory activity tested against inosine-5'-monophosphate dehydrogenase 2 (IMPDH-II) enzyme | B | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 3557-3560 [PMID:14505670] |
| GtoPdb | - | - | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2002) 45: 2127-30 [PMID:12014950] |
| ChEMBL | Inhibition of human inosine-5'-monophosphate dehydrogenase 2 | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2002) 45: 2127-2130 [PMID:12014950] |
| ChEMBL | Inhibitory activity against inosine monophosphate dehydrogenase IMPDH II | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 547-551 [PMID:12565969] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
