C1-27 [Ligand Id: 10719] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4210652
  • glutathione S-transferase omega 1/Glutathione transferase omega 1 in Human [ChEMBL: CHEMBL3174] [GtoPdb: 3110] [UniProtKB: P78417]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
glutathione S-transferase omega 1/Glutathione transferase omega 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3174] [GtoPdb: 3110] [UniProtKB: P78417]
ChEMBL Inhibition of recombinant GSTO1-1 (unknown origin) expressed in Escherichia coli assessed as inhibitor constant using S-(4-nitrophenacyl)glutathione as substrate preincubated for 1 to 6 mins followed by substrate addition by spectrophotmetric analysis B 6.36 pKi 440 nM Ki J Med Chem (2020) 63: 2894-2914 [PMID:32105470]
ChEMBL Inhibition of recombinant GSTO1-1 (unknown origin) expressed in Escherichia coli using S-(4-nitrophenacyl)glutathione as substrate preincubated for 2 mins followed by substrate addition by 4-NPG assay B 6.89 pIC50 130 nM IC50 J Med Chem (2020) 63: 2894-2914 [PMID:32105470]
GtoPdb - - 6.89 pIC50 130 nM IC50 J Med Chem (2020) 63: 2894-2914 [PMID:32105470]
ChEMBL Inhibition of GSTO1-1 (unknown origin) by enzymatic assay B 7.51 pIC50 31 nM IC50 J Med Chem (2018) 61: 7448-7470 [PMID:29652143]
ChEMBL Inhibition of CMFDA binding to human N-terminal 6x-His-tagged GSTO1-1 preincubated for 30 mins followed by CMFDA addition and measured after 30 mins by in-gel fluorescence binding assay B 7.68 pIC50 21 nM IC50 J Med Chem (2019) 62: 3068-3087 [PMID:30735370]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]