CWHM12 [Ligand Id: 10495] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3319237 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| integrin, alpha 10 subunit/integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/Integrin alpha-10/Integrin beta-1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430895] [GtoPdb: 2438, 2455] [UniProtKB: O75578, P05556] | ||||||||
| ChEMBL | Antagonist activity at alpha10beta1 integrin receptor (unknown origin) by cell-free ELISA | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (2014) 57: 6301-6315 [PMID:24568695] |
| integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/integrin, alpha 2 subunit (CD49B, alpha 2 subunit of VLA-2 receptor)/Integrin alpha2/beta1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3137268] [GtoPdb: 2455, 2440] [UniProtKB: P05556, P17301] | ||||||||
| ChEMBL | Antagonist activity at alpha2beta1 integrin receptor (unknown origin) by cell-free ELISA | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (2014) 57: 6301-6315 [PMID:24568695] |
| integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha IIb subunit (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)/Integrin alpha-IIb/beta-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2093869] [GtoPdb: 2457, 2441] [UniProtKB: P05106, P08514] | ||||||||
| ChEMBL | Antagonist activity at alpha2bbeta3 integrin receptor (unknown origin) by cell-free ELISA | B | 5.3 | pIC50 | >5000 | nM | IC50 | J Med Chem (2014) 57: 6301-6315 [PMID:24568695] |
| integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/integrin, alpha V subunit/Integrin alpha-V/beta-1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111407] [GtoPdb: 2455, 2453] [UniProtKB: P05556, P06756] | ||||||||
| ChEMBL | Antagonist activity at alphavbeta1 integrin receptor (unknown origin) by cell-free ELISA | B | 8.74 | pIC50 | 1.8 | nM | IC50 | J Med Chem (2014) 57: 6301-6315 [PMID:24568695] |
| ChEMBL | Inhibition of human fibronectin binding to human integrin alphavbeta1 after 2 hrs | B | 8.74 | pIC50 | 1.8 | nM | IC50 | J Med Chem (2019) 62: 7543-7556 [PMID:31381331] |
| integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha V subunit/Integrin alpha-V/beta-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907598] [GtoPdb: 2457, 2453] [UniProtKB: P05106, P06756] | ||||||||
| ChEMBL | Antagonist activity at alphavbeta3 integrin receptor (unknown origin) by cell-based ELISA | B | 9.1 | pIC50 | 0.8 | nM | IC50 | J Med Chem (2014) 57: 6301-6315 [PMID:24568695] |
| ChEMBL | Inhibition of integrin alphavbeta3 (unknown origin) by radioligand binding assay | B | 9.1 | pIC50 | 0.8 | nM | IC50 | J Med Chem (2019) 62: 7543-7556 [PMID:31381331] |
| integrin, alpha V subunit/integrin, beta 5 subunit/Integrin alpha-V/beta-5 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096675] [GtoPdb: 2453, 2459] [UniProtKB: P06756, P18084] | ||||||||
| ChEMBL | Antagonist activity at alphavbeta5 integrin receptor (unknown origin) by cell-based ELISA | B | 7.21 | pIC50 | 61 | nM | IC50 | J Med Chem (2014) 57: 6301-6315 [PMID:24568695] |
| ChEMBL | Inhibition of integrin alphavbeta5 (unknown origin) by radioligand binding assay | B | 7.21 | pIC50 | 61 | nM | IC50 | J Med Chem (2019) 62: 7543-7556 [PMID:31381331] |
| integrin, alpha V subunit/integrin, beta 6 subunit/Integrin alpha-V/beta-6 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111416] [GtoPdb: 2453, 2460] [UniProtKB: P06756, P18564] | ||||||||
| ChEMBL | Antagonist activity at alphavbeta6 integrin receptor (unknown origin) by cell-based ELISA | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (2014) 57: 6301-6315 [PMID:24568695] |
| ChEMBL | Inhibition of integrin alphavbeta6 (unknown origin) by radioligand binding assay | B | 8.82 | pIC50 | 1.5 | nM | IC50 | J Med Chem (2019) 62: 7543-7556 [PMID:31381331] |
| integrin, alpha V subunit/integrin, beta 8 subunit/Integrin alpha-V/beta-8 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430892] [GtoPdb: 2453, 2462] [UniProtKB: P06756, P26012] | ||||||||
| ChEMBL | Antagonist activity at alphavbeta8 integrin receptor (unknown origin) by cell-free ELISA | B | 9.7 | pIC50 | 0.2 | nM | IC50 | J Med Chem (2014) 57: 6301-6315 [PMID:24568695] |
| integrin αVβ3 in Human [GtoPdb: 2583] | ||||||||
| GtoPdb | IC50 determined in an in vitro ligand-binding assay. | - | 9.1 | pIC50 | 0.8 | nM | IC50 | Nat Med (2013) 19: 1617-24 [PMID:24216753] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
