bremelanotide [Ligand Id: 10408] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL2070241 |
|---|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| MC1 receptor in Human [GtoPdb: 282] [UniProtKB: Q01726] | ||||||||
| GtoPdb | Inhibition of 125I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC1 receptor. | - | 8.19 | pKi | 6.4 | nM | Ki | J Med Chem (2012) 55: 1969-77 [PMID:22335602] |
| MC3 receptor in Human [GtoPdb: 284] [UniProtKB: P41968] | ||||||||
| GtoPdb | Inhibition of 125I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC3 receptor. | - | 7.28 | pKi | 53 | nM | Ki | J Med Chem (2012) 55: 1969-77 [PMID:22335602] |
| MC4 receptor in Human [GtoPdb: 285] [UniProtKB: P32245] | ||||||||
| GtoPdb | Inhibition of 125I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC4 receptor. | - | 9.6 | pKi | 0.25 | nM | Ki |
J Med Chem (2012) 55: 1969-77 [PMID:22335602]; Obstet Gynecol (2019) 134: 899-908 [PMID:31599840] |
| MC5 receptor in Human [GtoPdb: 286] [UniProtKB: P33032] | ||||||||
| GtoPdb | Inhibition of 125I-NDP-αMSH binding to membranes from BHK570 cells stably expressing human MC5 receptor. | - | 7.77 | pKi | 17 | nM | Ki | J Med Chem (2012) 55: 1969-77 [PMID:22335602] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
