ONO-2333MS [Ligand Id: 10376] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1819077 (Ono-2333ms) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CRF1 receptor/Corticotropin releasing factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1800] [GtoPdb: 212] [UniProtKB: P34998] | ||||||||
| ChEMBL | Displacement of [125I]CRF from human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells after 2 hrs by gamma counting | B | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem (2011) 19: 5432-5445 [PMID:21865047] |
| GtoPdb | - | - | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem (2011) 19: 5432-45 [PMID:21865047] |
| ChEMBL | Antagonist activity at human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP production after 15 mins by enzyme immunoassay | F | 7.4 | pEC50 | 40 | nM | EC50 | Bioorg Med Chem (2011) 19: 5432-5445 [PMID:21865047] |
| CRF1 receptor/Corticotropin releasing factor receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4649] [GtoPdb: 212] [UniProtKB: P35353] | ||||||||
| ChEMBL | Displacement of [125I]CRF from corticotropin-releasing factor receptor 1 in rat brain membranes after 2 hrs by gamma counting | B | 8.15 | pIC50 | 7 | nM | IC50 | Bioorg Med Chem (2011) 19: 5432-5445 [PMID:21865047] |
| ChEMBL | Antagonist activity at rat corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP production after 15 mins by enzyme immunoassay | F | 7.4 | pEC50 | 40 | nM | EC50 | Bioorg Med Chem (2011) 19: 5432-5445 [PMID:21865047] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
