ChEMBL ligand: CHEMBL260920
protein tyrosine phosphatase non-receptor type 22/Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP in Human [ChEMBL: CHEMBL2889] [GtoPdb: 3084] [UniProtKB: Q9Y2R2] There should be some charts here, you may need to enable JavaScript!
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] There should be some charts here, you may need to enable JavaScript!
Protein-tyrosine phosphatase 1E in Human [ChEMBL: CHEMBL2976] [UniProtKB: Q12923] There should be some charts here, you may need to enable JavaScript!
protein tyrosine phosphatase non-receptor type 11/Protein-tyrosine phosphatase 2C in Human [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124] There should be some charts here, you may need to enable JavaScript!
Protein-tyrosine phosphatase LC-PTP in Human [ChEMBL: CHEMBL2219] [UniProtKB: P35236] There should be some charts here, you may need to enable JavaScript!
Tyrosine-protein phosphatase non-receptor type 9 in Human [ChEMBL: CHEMBL6117] [UniProtKB: P43378] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
protein tyrosine phosphatase non-receptor type 22/Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2889] [GtoPdb: 3084] [UniProtKB: Q9Y2R2]
ChEMBL	Inhibition of LYP expressed in Escherichia coli BL21 using increasing levels of ARLIED-NEpYTAREG substrate	B	4.47	pKi	33870	nM	Ki	J Med Chem (2011) 54: 1640-1654 [PMID:21341673]
ChEMBL	Competitive inhibition of N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) expressed in Escherichia coli BL21(DE3) using pNPP as substrate by Dixon plot analysis	B	5.54	pKi	2900	nM	Ki	J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
GtoPdb	-	-	5.54	pKi	2900	nM	Ki	Proc Natl Acad Sci USA (2007) 104: 19767-72 [PMID:18056643]
ChEMBL	Inhibition of lymphoid-specific tyrosine phosphatase F28A mutant	B	4.46	pIC50	35000	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643]
ChEMBL	Inhibition of lymphoid-specific tyrosine phosphatase S35E mutant	B	4.68	pIC50	21000	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643]
ChEMBL	Inhibition of lymphoid-specific tyrosine phosphatase K138A mutant	B	4.72	pIC50	19000	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643]
ChEMBL	Inhibition of lymphoid-specific tyrosine phosphatase R33A mutant	B	4.9	pIC50	12500	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643]
ChEMBL	Inhibition of lymphoid-specific tyrosine phosphatase L29A mutant	B	4.93	pIC50	11800	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643]
ChEMBL	Inhibition of lymphoid-specific tyrosine phosphatase C129S mutant	B	5.09	pIC50	8100	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643]
ChEMBL	Inhibition of lymphoid-specific tyrosine phosphatase	B	5.34	pIC50	4600	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643]
ChEMBL	Inhibition of Lyp-mediated pNPP hydrolysis	B	5.34	pIC50	4600	nM	IC50	Bioorg Med Chem (2012) 20: 1940-1946 [PMID:22133902]
ChEMBL	Inhibition of N-terminal 6xHis-tagged LYP catalytic domain (1 to 294) (unknown origin) expressed in Escherichia coli BL21(DE3) using pNPP as substrate by spectrometric analysis	B	5.34	pIC50	4600	nM	IC50	J Med Chem (2013) 56: 4990-5008 [PMID:23713581]
GtoPdb	In vitro measurement of PTPN22-catalysed substrate dephosphorylation, using pNPP as a substrate at pH 7.0, 25°C, and ionic strength of 0.15 M.	-	5.34	pIC50	4600	nM	IC50	Proc Natl Acad Sci USA (2007) 104: 19767-72 [PMID:18056643]
ChEMBL	Inhibition of recombinant LyP assessed as hydrolysis of DiFMUP	B	5.35	pIC50	4500	nM	IC50	J Med Chem (2011) 54: 562-571 [PMID:21190368]
ChEMBL	Inhibition of lymphoid-specific tyrosine phosphatase T36E mutant	B	5.55	pIC50	2800	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643]
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
ChEMBL	Inhibition of PTP1B	B	4.93	pIC50	11800	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643]
GtoPdb	-	-	4.93	pIC50	11800	nM	IC50	Proc Natl Acad Sci USA (2007) 104: 19767-72 [PMID:18056643]
Protein-tyrosine phosphatase 1E in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2976] [UniProtKB: Q12923]
ChEMBL	Inhibition of FAP1	B	4.43	pIC50	36800	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643]
protein tyrosine phosphatase non-receptor type 11/Protein-tyrosine phosphatase 2C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3864] [GtoPdb: 3203] [UniProtKB: Q06124]
ChEMBL	Inhibition of SHP2	B	4.44	pIC50	36000	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643]
Protein-tyrosine phosphatase LC-PTP in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2219] [UniProtKB: P35236]
ChEMBL	Inhibition of HePTP	B	4.49	pIC50	32100	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643]
Tyrosine-protein phosphatase non-receptor type 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6117] [UniProtKB: P43378]
ChEMBL	Inhibition of PTP-Meg2	B	4.5	pIC50	31800	nM	IC50	Proc Natl Acad Sci U S A (2007) 104: 19767-19772 [PMID:18056643]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]