purmorphamine [Ligand Id: 10356] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1221984 (Purmorphamine)
  • secretin receptor/Secretin receptor in Human [ChEMBL: CHEMBL1925] [GtoPdb: 252] [UniProtKB: P47872]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
secretin receptor/Secretin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1925] [GtoPdb: 252] [UniProtKB: P47872]
ChEMBL Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 100 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit) F 7.07 pEC50 85.51 nM EC50 Eur J Med Chem (2022) 242: 114642-114642 [PMID:35987021]
ChEMBL Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 1 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit) F 7.17 pEC50 68.08 nM EC50 Eur J Med Chem (2022) 242: 114642-114642 [PMID:35987021]
ChEMBL Positive allosteric modulation of SCTR (unknown origin) expressed in CHO cells assessed as potentiation of SCT-induced cAMP production by measuring secretin EC50 at 10 uM incubated for 20 mins in presence of 1 uM SCT by Lance cAMP assay (Rvb = 7.77 +/- 0.116 No_unit) F 7.39 pEC50 40.55 nM EC50 Eur J Med Chem (2022) 242: 114642-114642 [PMID:35987021]
SMO/Smoothened homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5971] [GtoPdb: 239] [UniProtKB: Q99835]
ChEMBL Inhibition of BODIPY-cyclopamine binding to Smo expressed in HEK293T cells after 1 hr by fluorescence microscopy B 5.82 pIC50 1500 nM IC50 Nat Chem Biol (2006) 2: 29-30 [PMID:16408088]
GtoPdb - - 6 pEC50 ~1000 nM EC50 Nat Chem Biol (2006) 2: 29-30 [PMID:16408088]
ChEMBL Agonist activity at SMO receptor (unknown origin) B 6 pEC50 1000 nM EC50 J Nat Prod (2023) 86: 157-165 [PMID:36547402]
SMO/Smoothened homolog in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6080] [GtoPdb: 239] [UniProtKB: P56726]
ChEMBL Activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assay B 6.1 pEC50 800 nM EC50 Eur J Med Chem (2016) 121: 747-757 [PMID:27429255]
Sonic hedgehog protein in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5387] [UniProtKB: Q62226]
ChEMBL Activation of Shh in mouse Shh Light2 cells after 30 hrs by luciferase reporter gene assay F 6 pEC50 1000 nM EC50 Nat Chem Biol (2006) 2: 29-30 [PMID:16408088]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]