BL-1249 [Ligand Id: 10336] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1417584 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| K2P10.1/Potassium channel subfamily K member 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331041] [GtoPdb: 521] [UniProtKB: P57789] | ||||||||
| GtoPdb | - | - | 5.1 | pEC50 | 8000 | nM | EC50 | ACS Chem Neurosci (2018) 9: 3153-3165 [PMID:30089357] |
| ChEMBL | Activation of human TREK2 by thallium flux mobilization assay | B | 5.11 | pEC50 | 7700 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 1601-1604 [PMID:31072652] |
| K2P18.1/Potassium channel subfamily K member 18 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331042] [GtoPdb: 527] [UniProtKB: Q7Z418] | ||||||||
| ChEMBL | Activation of human TRESK channel relative to control | B | 5.22 | pEC50 | 6000 | nM | EC50 | Bioorg Med Chem Lett (2016) 26: 4919-4924 [PMID:27641472] |
| K2P2.1/Potassium channel subfamily K member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2321615] [GtoPdb: 514] [UniProtKB: O95069] | ||||||||
| GtoPdb | - | - | 5.26 | pEC50 | 5500 | nM | EC50 | ACS Chem Neurosci (2018) 9: 3153-3165 [PMID:30089357] |
| ChEMBL | Activation of human TREK1 by thallium flux mobilization assay | B | 5.28 | pEC50 | 5200 | nM | EC50 | Bioorg Med Chem Lett (2019) 29: 1601-1604 [PMID:31072652] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
