BL-1249 [Ligand Id: 10336] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1417584
  • K2P10.1/Potassium channel subfamily K member 10 in Human [ChEMBL: CHEMBL2331041] [GtoPdb: 521] [UniProtKB: P57789]
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  • K2P18.1/Potassium channel subfamily K member 18 in Human [ChEMBL: CHEMBL2331042] [GtoPdb: 527] [UniProtKB: Q7Z418]
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  • K2P2.1/Potassium channel subfamily K member 2 in Human [ChEMBL: CHEMBL2321615] [GtoPdb: 514] [UniProtKB: O95069]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
K2P10.1/Potassium channel subfamily K member 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331041] [GtoPdb: 521] [UniProtKB: P57789]
GtoPdb - - 5.1 pEC50 8000 nM EC50 ACS Chem Neurosci (2018) 9: 3153-3165 [PMID:30089357]
ChEMBL Activation of human TREK2 by thallium flux mobilization assay B 5.11 pEC50 7700 nM EC50 Bioorg Med Chem Lett (2019) 29: 1601-1604 [PMID:31072652]
K2P18.1/Potassium channel subfamily K member 18 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331042] [GtoPdb: 527] [UniProtKB: Q7Z418]
ChEMBL Activation of human TRESK channel relative to control B 5.22 pEC50 6000 nM EC50 Bioorg Med Chem Lett (2016) 26: 4919-4924 [PMID:27641472]
K2P2.1/Potassium channel subfamily K member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2321615] [GtoPdb: 514] [UniProtKB: O95069]
GtoPdb - - 5.26 pEC50 5500 nM EC50 ACS Chem Neurosci (2018) 9: 3153-3165 [PMID:30089357]
ChEMBL Activation of human TREK1 by thallium flux mobilization assay B 5.28 pEC50 5200 nM EC50 Bioorg Med Chem Lett (2019) 29: 1601-1604 [PMID:31072652]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]