SANT-2 [Ligand Id: 10331] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL514344
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  • SMO in Mouse [GtoPdb: 239] [UniProtKB: P56726]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Sonic hedgehog protein in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5387] [UniProtKB: Q62226]
ChEMBL Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG F 7.01 pIC50 97.9 nM IC50 Bioorg Med Chem (2009) 17: 4943-4954 [PMID:19541490]
ChEMBL Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assay B 7.52 pIC50 30 nM IC50 J Med Chem (2009) 52: 3829-3845 [PMID:19309080]
SMO in Mouse [GtoPdb: 239] [UniProtKB: P56726]
GtoPdb In Gli-dependent reporter assays in Shh-LIGHT2 cells. - 7.52 pIC50 30 nM IC50 Proc Natl Acad Sci USA (2002) 99: 14071-6 [PMID:12391318]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]