SC-236 [Ligand Id: 10242] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL282093 (SC-58236) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
| ChEMBL | Inhibition of COX1 | B | 4.5 | pIC50 | 31400 | nM | IC50 | J Nat Prod (2002) 65: 163-169 [PMID:11858749] |
| ChEMBL | In vitro inhibitory concentration required to block recombinant human prostaglandin G/H synthase 1 (COX-1) | B | 4.75 | pIC50 | 17800 | nM | IC50 | J Med Chem (1997) 40: 1347-1365 [PMID:9135032] |
| GtoPdb | - | - | 4.75 | pIC50 | 17800 | nM | IC50 | J Med Chem (1997) 40: 1347-65 [PMID:9135032] |
| GtoPdb | - | - | 4.75 | pIC50 | 17800 | nM | IC50 | J Med Chem (1997) 40: 1347-65 [PMID:9135032] |
| Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979] | ||||||||
| ChEMBL | Inhibitory activity against prostaglandin G/H synthase 1 (COX-1) | B | 4.75 | pIC50 | 17782.79 | nM | IC50 | J Med Chem (2002) 45: 4816-4827 [PMID:12383007] |
| COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] | ||||||||
| ChEMBL | Inhibition of human Prostaglandin G/H synthase 2 | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2001) 44: 3223-3230 [PMID:11563921] |
| ChEMBL | Inhibitory concentration against human prostaglandin G/H synthase 2 at 25 degrees. | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 267-270 [PMID:11814774] |
| ChEMBL | In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2) | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (1997) 40: 1347-1365 [PMID:9135032] |
| GtoPdb | - | - | 8.3 | pIC50 | 5 | nM | IC50 |
J Med Chem (1997) 40: 1347-65 [PMID:9135032]; J Biol Chem (1996) 271: 15810-4 [PMID:8663121] |
| ChEMBL | Inhibition of COX2 | B | 9.35 | pIC50 | 0.45 | nM | IC50 | J Nat Prod (2002) 65: 163-169 [PMID:11858749] |
| COX-2 /Cyclooxygenase-2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4321] [GtoPdb: 1376] [UniProtKB: Q05769] | ||||||||
| ChEMBL | Inhibitory activity against prostaglandin G/H synthase 2 (COX-2) | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2002) 45: 4816-4827 [PMID:12383007] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
