fMet-Leu-Phe [Ligand Id: 1022] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL267179 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| FML2_HUMAN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5646] [UniProtKB: Q6L5J4] | ||||||||
| ChEMBL | Agonist activity at FPRL2 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay | F | 5.72 | pEC50 | 1900 | nM | EC50 | J Med Chem (2009) 52: 5044-5057 [PMID:19639995] |
| FPR1/Formyl peptide receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3359] [GtoPdb: 222] [UniProtKB: P21462] | ||||||||
| ChEMBL | Binding affinity to human FPR1 receptor | B | 8.52 | pKd | 3 | nM | Kd | J Med Chem (2015) 58: 1089-1099 [PMID:25587631] |
| ChEMBL | Displacement of [3H]-fMLP from FPR in human neutrophils | B | 7.38 | pKi | 42 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 3696-3701 [PMID:17475488] |
| ChEMBL | Binding affinity towards fMLF receptor using human neutrophils | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (1996) 39: 1013-1015 [PMID:8676333] |
| ChEMBL | Agonistic activity was determined by measuring the ability to induce superoxide production(as measured by reduction of cytochrome C) using human neutrophils | F | 7.7 | pEC50 | 20 | nM | EC50 | J Med Chem (1996) 39: 1013-1015 [PMID:8676333] |
| ChEMBL | Agonist activity at FPR1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay | F | 8 | pEC50 | 10 | nM | EC50 | J Med Chem (2009) 52: 5044-5057 [PMID:19639995] |
| GtoPdb | - | - | 10.2 | pEC50 | - | - | - |
J Exp Med (1976) 143: 1154-69 [PMID:1262785]; Biochemistry (1980) 19: 2404-10 [PMID:7387981] |
| FPR1 in Mouse [GtoPdb: 222] [UniProtKB: P33766] | ||||||||
| GtoPdb | - | - | 4.7 | pEC50 | - | - | - |
J Exp Med (1999) 190: 741-7 [PMID:10477558]; J Immunol (2008) 181: 1429-37 [PMID:18606697] |
| FPR3/Formyl peptide receptor-related sequence 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3407315] [GtoPdb: 224] [UniProtKB: O08790] | ||||||||
| ChEMBL | Binding affinity to mouse FPR2 receptor | B | 6.52 | pKd | >300 | nM | Kd | J Med Chem (2015) 58: 1089-1099 [PMID:25587631] |
| FPR2/ALX/Lipoxin A4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4227] [GtoPdb: 223] [UniProtKB: P25090] | ||||||||
| GtoPdb | - | - | 6.37 | pKd | - | - | - | J Biol Chem (1993) 268: 18167-75 [PMID:8349692] |
| ChEMBL | Binding affinity to human FPR2 receptor | B | 6.52 | pKd | >300 | nM | Kd | J Med Chem (2015) 58: 1089-1099 [PMID:25587631] |
| ChEMBL | Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay | F | 4.69 | pEC50 | 20400 | nM | EC50 | J Med Chem (2009) 52: 5044-5057 [PMID:19639995] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
