GPR4 antagonist 3b [Ligand Id: 10207] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL3810385 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GPR4/G-protein coupled receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3638324] [GtoPdb: 84] [UniProtKB: P46093] | ||||||||
| GtoPdb | - | - | 7.17 | pIC50 | 67 | nM | IC50 | ACS Med Chem Lett (2016) 7: 493-7 [PMID:27190599] |
| ChEMBL | Antagonist activity at N-terminal HA-tagged GPR4 (unknown origin) expressed in HEK293 cells assessed as inhibition of pH dependent cAMP response element-driven transcriptional activity at pH 7.2 incubated for 6 hrs by dual luciferase reporter gene assay | F | 7.17 | pIC50 | 67 | nM | IC50 | ACS Med Chem Lett (2016) 7: 493-497 [PMID:27190599] |
| GPR68/Ovarian cancer G-protein coupled receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3713916] [GtoPdb: 114] [UniProtKB: Q15743] | ||||||||
| ChEMBL | Antagonist activity at N-terminal HA-tagged OGR1 (unknown origin) expressed in HEK293 cells assessed as inhibition of pH dependent nuclear factor of activated T-cell activity at pH 7.2 incubated for 6 hrs by dual luciferase reporter gene assay | B | 5 | pIC50 | >10000 | nM | IC50 | ACS Med Chem Lett (2016) 7: 493-497 [PMID:27190599] |
| GPR65/Psychosine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3714081] [GtoPdb: 113] [UniProtKB: Q8IYL9] | ||||||||
| ChEMBL | Antagonist activity at N-terminal HA-tagged TDAG8 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of pH dependent cAMP response element-driven transcriptional activity at pH 7.2 incubated for 6 hrs by dual luciferase reporter gene assay | F | 5 | pIC50 | >10000 | nM | IC50 | ACS Med Chem Lett (2016) 7: 493-497 [PMID:27190599] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
