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This section gives an overview of the disease, and where available shows the following:
More information can be found in the help pages.
✖Disease ID: | 608 | |
Name: | Major affective disorder 2; MAFD2 | |
Associated with: | 1 target |
Click on the target name to link to its detailed view page
Where available, information is display on the role of the target in the disease; drugs which target the disease and their therapeutic use and side-effects.
If there is mutation data curated in GtoPdb this is indicated, with a link back to the appropriate section on the target detailed view page
Immuno ligand interactions - If available, a table of immuno-relevant ligands is shown. These ligands have been curated as having an association to the disease and possess interaction data with the target in GtoPdb. The approval status of the ligand is shown, along with curator comments and an indication of whether the target is considered the primary target of the ligand.
More information can be found in the help pages.
✖GPR50 | |
Comments: | A role for GPR50 in mental disorders, such as Alzheimer's and schizophrenia, has been postulated . |
References: | 1-2 |
Mutations: | GPR50 is associated with 1 mutation. Click here for details ![]() |
Click ligand name to view ligand summary page
Click the arrow in the final column to expand comments
More information can be found in the help pages.
✖No ligand related data available for Major affective disorder 2; MAFD2
1. Gerwins P, Nordstedt C, Fredholm BB. (1990) Characterization of adenosine A1 receptors in intact DDT1 MF-2 smooth muscle cells. Mol Pharmacol, 38 (5): 660-6. [PMID:2172773]
2. Grünewald E, Kinnell HL, Porteous DJ, Thomson PA. (2009) GPR50 interacts with neuronal NOGO-A and affects neurite outgrowth. Mol Cell Neurosci, 42 (4): 363-71. [PMID:19699797]
3. Macintyre DJ, McGhee KA, Maclean AW, Afzal M, Briffa K, Henry B, Thomson PA, Muir WJ, Blackwood DH. (2010) Association of GPR50, an X-linked orphan G protein-coupled receptor, and affective disorder in an independent sample of the Scottish population. Neurosci Lett, 475 (3): 169-73. [PMID:20371266]