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Cardiac arrhythmia

Disease ID:177
Name:Cardiac arrhythmia
Associated with:2 targets


Role:  Supraventricular tachycardias caused by re-entrant circuits.
Drugs:  Adenosine (activation of Kir3.1/3.4 via purinergic receptors).
Side effects:  Flushing, rapid heart rate, nausea.
Therapeutic use:  To restore normal sinus rhythm.
References:  1
Drugs:  Verapamil, methoxyverapamil, diltiazem
References:  2-3


No ligand related data available for Cardiac arrhythmia


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1. Armstrong A, Clapham DE. (2007) Pharmacology of Cardiac Rhythm. In Principles of pharmacology: the pathophysiologic basis of drug therapy (2nd edition). Edited by Dolan DE, Tashjian AH, Armstrong EJ, Armstrong AW (Lipponcott Williams and Wilkins) 307-324. [ISBN:0781783550]

2. Patten M, Maas R, Bauer P, Lüderitz B, Sonntag F, Dluzniewski M, Hatala R, Opolski G, Müller HW, Meinertz T et al.. (2004) Suppression of paroxysmal atrial tachyarrhythmias--results of the SOPAT trial. Eur Heart J, 25 (16): 1395-404. [PMID:15321697]

3. Poole-Wilson PA, Lubsen J, Kirwan BA, van Dalen FJ, Wagener G, Danchin N, Just H, Fox KA, Pocock SJ, Clayton TC et al.. (2004) Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomised controlled trial. Lancet, 364 (9437): 849-57. [PMID:15351192]