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Allergic urticaria

GtoPdb Disease Summaries

This section gives an overview of the disease, and where available shows the following:

  • Synonyms: Shows known synonyms for the disease.
  • Description: Gives a basic description/definition of the disease.
  • Database Link: External links to the same disease at the Disease Ontology, OMIM or Orphanet sites.
  • Immunopharmacology comments: General comments about the target's role in immunopharmacology, provided by GtoImmuPdb curators.
  • Associated with: Counts are displayed for the total targets the disease is associated with in GtoPdb. The counts of targets and ligands of immunological relevance associated to the disease are also shown.

More information can be found in the help pages.

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Disease ID:1191
Name:Allergic urticaria
Associated with:0 target
10 immuno-relevant ligands
Synonyms
hives
Description
A skin rash with red, raised, itchy bumps as a result of an allergic reaction to drugs, insect bites, or food for example.
Database Links
Disease Ontology: DOID:10612

Targets

GtoPdb Disease Summaries - Targets

Click on the target name to link to its detailed view page

Where available, information is display on the role of the target in the disease; drugs which target the disease and their therapeutic use and side-effects.

If there is mutation data curated in GtoPdb this is indicated, with a link back to the appropriate section on the target detailed view page

Immuno ligand interactions - If available, a table of immuno-relevant ligands is shown. These ligands have been curated as having an association to the disease and possess interaction data with the target in GtoPdb. The approval status of the ligand is shown, along with curator comments and an indication of whether the target is considered the primary target of the ligand.

More information can be found in the help pages.

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Key to terms and symbols

No target related data available for Allergic urticaria

Ligands

GtoPdb Disease Summaries - Ligands

Click ligand name to view ligand summary page

  • Approved: If the ligand is an approved drug this is indicated, along with approval bodies.
  • Immuno: Immuno icon indicates the ligand is immuno-relevant

Click the arrow in the final column to expand comments

  • Immuno Disease Comments: Curatorial comments specifically added as part of GtoImmuPdb. They give more information on the association between the ligand and disease in the context of immunopharmacology.
  • Clinical Use: General clinical comments relating to the ligand and may not necessarily be specific to the disease in question. With hyperlink to more details on the ligand summary pages.
  • Bioactivty Comments: Curatorial comments specifically about the compounds biological activity - with hyperlink to more details on the ligand summary pages.

More information can be found in the help pages.

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Key to terms and symbols Click ligand name to view ligand summary Click column headers to sort
Ligand References Clinical and Disease comments
fexofenadine
Immuno Disease Comments: Antihistamine approved for the treatment of the symptoms of chronic idiopathic urticaria.
Clinical Use: Fexofenadine is used to treat the symptoms of seasonal allergies and other histamine-dependent conditions. | View clinical data
clemastine
Immuno Disease Comments: The sedative effect of clemastine can aid sleep in patients suffering from allergic urticaria.
Clinical Use: Used to treat hay fever, rhinitis, allergic skin conditions, and pruritus | View clinical data
Bioactivity Comments: Clemastine is one of a number of drugs that are cationic amphiphilic in nature, for which anti-SARS-CoV-2 activity has been identified in drug repurposing screens. Tummino et al. (2021; bioRxiv preprint PMID: 33791693 target="_blank") suggest that this antiviral activity is most likely a result of the drug promoting phospholipidosis via disruption of lipid homeostasis. | View biological activity
amcinonide
Immuno Disease Comments: Topically applied corticosteroid used to treat itching and inflammation associated with allergic and other inflammatory skin conditions
Clinical Use: Used to treat itching and inflammation associated with allergic and other inflammatory skin conditions. | View clinical data
fluocinolone acetonide
Immuno Disease Comments: A topically applied corticosteroid used to treat inflammatory and pruritic skin conditions.
Clinical Use: Fluocinolone acetonide is the active component in creams used to treat inflammatory and pruritic skin conditions. An intravitreal implant containing fluocinolone acetonide was approved (by the US FDA) for the management of diabetic macular edema in 2014. The Yutiq® intravitreal implant containing fluocinolone acetonide was FDA approved for the treatment of non-infectious posterior uveitis in October 2018. | View clinical data
fluocinonide
Immuno Disease Comments: A topically applied corticosteroid used to treat inflammatory and pruritic skin conditions
Clinical Use: Fluocinonide is the active component in creams used to treat inflammatory and pruritic skin conditions. | View clinical data
azatadine
Immuno Disease Comments: Approved drug for allergic urticaria.
Clinical Use: Used to reduce symptoms of allergies (such as sneezing, itching, runny nose and watery eyes, rashes). | View clinical data
Bioactivity Comments: We have been unable to find publicly available affinity data for this drug at its proposed molecular target to substantiate its MMOA, and have therefore not tagged a primary drug target. | View biological activity
desloratadine
Immuno Disease Comments: Antihistamine approved for many allergic conditions.
Clinical Use: Desloratadine is used to treat the symptoms (eg rhinitis and urticaria) of many allergic conditions. In some countries this drug is available without prescription. | View clinical data
Bioactivity Comments: Desloratidine is one of a number of drugs that are cationic amphiphilic in nature, for which anti-SARS-CoV-2 activity has been identified in drug repurposing screens. Tummino et al. (2021; bioRxiv preprint PMID: 33791693 target="_blank") suggest that this antiviral activity is most likely a result of the drug promoting phospholipidosis via disruption of lipid homeostasis. | View biological activity
diphenylpyraline
Immuno Disease Comments: Antihistamine approved for allergic urticaria.
Clinical Use: Diphenylpyraline is an antihistamine used to treat allergic rhinitis, hay fever, and allergic skin disorders. There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation. | View clinical data
Bioactivity Comments: We have been unable to find publicly available affinity data for this drug at its proposed molecular target to substantiate its MMOA, and have therefore not tagged a primary drug target. | View biological activity
tripelennamine
Immuno Disease Comments: Antihistamine approved for allergic urticaria.
Clinical Use: Used as an antipruritic and antihistamine in the treatment of asthma, hay fever, rhinitus and urticaria. All formulations of this drug appear to have been discontinued by the US FDA, although other national approval agencies may continue to grant marketing authorisation. | View clinical data
mepyramine
Immuno Disease Comments: Mepyramine is a topically applied antihistamine that can be used to treat allergic urticaria and the inflammation associated with bites and stings.
Clinical Use: Mepyramine suppresses the symptoms of allergic rhinitis. This drug does not have marketing approval in the US or European Union. Other national approval agencies may have granted marketing authorisation. For example, in the UK mepyramine is the active ingredient in a number of over the counter bite and sting relief antihistamine creams. In some countries mepyramine may only be used in veterinary practice. | View clinical data
Bioactivity Comments: The drug is administered as the maleate salt which has PubChem CID 5284451. | View biological activity