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Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 519 | 18q11.2 | RIOK3 | RIO kinase 3 | |
Mouse | - | 519 | 18 6.15 cM | Riok3 | RIO kinase 3 | |
Rat | - | 519 | 18 p13 | Riok3 | RIO kinase 3 |
Previous and Unofficial Names ![]() |
SUDD |
Database Links ![]() |
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Alphafold | O14730 (Hs), Q9DBU3 (Mm) |
BRENDA | 2.7.11.1 |
ChEMBL Target | CHEMBL5659 (Hs) |
Ensembl Gene | ENSG00000101782 (Hs), ENSMUSG00000024404 (Mm), ENSRNOG00000023376 (Rn) |
Entrez Gene | 8780 (Hs), 66878 (Mm), 361293 (Rn) |
Human Protein Atlas | ENSG00000101782 (Hs) |
KEGG Enzyme | 2.7.11.1 |
KEGG Gene | hsa:8780 (Hs), mmu:66878 (Mm), rno:361293 (Rn) |
OMIM | 603579 (Hs) |
Pharos | O14730 (Hs) |
RefSeq Nucleotide | NM_003831 (Hs), NM_024182 (Mm), NM_001108423 (Rn) |
RefSeq Protein | NP_003822 (Hs), NP_077144 (Mm), NP_001101893 (Rn) |
UniProtKB | O14730 (Hs), Q9DBU3 (Mm) |
Wikipedia | RIOK3 (Hs) |
Enzyme Reaction ![]() |
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DiscoveRx KINOMEscan® screen ![]() |
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A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1-2 |
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Target used in screen: RIOK3 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
Immuno Process Associations | ||
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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
RIO3 subfamily: RIO kinase 3. Last modified on 18/08/2014. Accessed on 20/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2188.