Unknown MOA
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.5 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.5
(IC50 2.9x10-9 M)
[3H]-hypoxanthine incorporation
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Unknown MOA
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.4 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.4
(IC50 4.2x10-9 M)
[3H]-hypoxanthine incorporation
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Unknown MOA
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.4 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.4
(IC50 4.2x10-9 M)
[3H]-hypoxanthine incorporation
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Unknown MOA
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.4 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.4
(IC50 4.2x10-9 M)
[3H]-hypoxanthine incorporation
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Unknown MOA
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.3 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.3
(IC50 5.1x10-9 M)
[3H]-hypoxanthine incorporation
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Unknown MOA
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.3 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.3
(IC50 5.2x10-9 M)
[3H]-hypoxanthine incorporation
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Unknown MOA
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.1 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.1
(IC50 7.3x10-9 M)
[3H]-hypoxanthine incorporation
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Unknown MOA
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.1 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.1
(IC50 7.7x10-9 M)
[3H]-hypoxanthine incorporation
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Unknown MOA
|
|
|
|
Parasite growth inhibition assay |
- |
- |
8.1 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
8.1
(IC50 8.5x10-9 M)
[3H]-hypoxanthine incorporation
[1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
|
Unknown MOA
|
|
|
|
Standard membrane feeding assay (SMFA) |
- |
- |
7.8 |
pIC50 |
- |
1 |
|
⤷ |
pIC50
7.8
(IC50 1.45x10-8 M)
determined by the reduction in oocyst mean intensity. A corresponding ~60 and 90% transmission blocking activity (defined as the percentage of mosquitoes with no observed oocysts) was determined at 100nM and 1µM, respectively
[1]
Lifecycle stages: Plasmodium mosquito host stage (gametocyte, gamete, zygote, ookinete, oocyst, sporozoite)
|