Synonyms: all-trans-retinol
Compound class:
Metabolite
Comment: Retinol (vitamin A1) plays an essential role in (night) vision, normal bone and tooth development, reproduction, and is required for maintaining the integrity of skin and mucous membranes. It has antioxidant activity.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖View more information in the IUPHAR Pharmacology Education Project: retinol |
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Natural/Endogenous Targets | ||
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Selectivity at nuclear hormone receptors | ||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click column headers to sort | |||||||||||||||||||||||||||||||||
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Additional information and targets (data relate to human unless otherwise stated) | ||
Description | Data | Reference |
Rank order of potency at retinaldehyde binding protein 1 | 11-cis-retinal, 11-cis-retinol > 9-cis-retinal, 13-cis-retinal, 13-cis-retinol, all-trans-retinal, retinol | 1 |
Targets where the ligand is described in the comment field | |
Target | Comment |
CYP27C1 | Converts retinol (vitamin A1) to 3,4-didehydroretinol (vitamin A2) [2]. |