retinol [Ligand Id: 4053] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL986 (Aquasol a, Arovit, Nepalm, NSC-122759, Oleovitamin a, Retinol, Retinol acetate, Retinol palmitate, Retinol (vit a), Ro-a-vit, Vitamin a, Vitamin A, Vitamin A 1, Vitamin a oil, Vitamin A Solubilized) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| synuclein alpha/Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [GtoPdb: 3285] [UniProtKB: P37840] | ||||||||
| ChEMBL | Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay | B | 6.72 | pIC50 | 190 | nM | IC50 | Eur J Med Chem (2019) 167: 10-36 [PMID:30743095] |
| Amyloid-beta A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067] | ||||||||
| ChEMBL | Inhibition of amyloid beta (1 to 40) (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay | B | 6.74 | pIC50 | 180 | nM | IC50 | Eur J Med Chem (2019) 167: 10-36 [PMID:30743095] |
| Beta-lactoglobulin in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075053] [UniProtKB: P02754] | ||||||||
| ChEMBL | Binding affinity to bovine beta-lactoglobulins by fluorescence spectroscopy | B | 7.44 | pKd | 36 | nM | Kd | J Med Chem (2010) 53: 514-518 [PMID:19938842] |
| retinol binding protein 4/Plasma retinol-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3100] [GtoPdb: 2549] [UniProtKB: P02753] | ||||||||
| ChEMBL | Binding affinity to His-tagged recombinant human sRBP expressed in Escherichia coli BL21(DE3) assessed as apparent dissociation constant after 5 mins by fluorescence spectrophotometric analysis | B | 6.74 | pKd | 182 | nM | Kd | J Med Chem (2011) 54: 4378-4387 [PMID:21591606] |
| Testicular receptor 4 in Human [GtoPdb: 614] [UniProtKB: P49116] | ||||||||
| GtoPdb | - | - | 4.71 | pEC50 | 19400 | nM | EC50 | J Biol Chem (2011) 286: 2877-85 [PMID:21068381] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
