Mitochondrial-associated proteins

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Mitochondrial-associated proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Targets

2879

Translocator protein Show summary »« Hide summary

Target Id

2879

Nomenclature

Translocator protein

Previous and unofficial names

Mitochondrial benzodiazepine receptor | Peripheral-type benzodiazepine receptor | translocator protein (18kDa)

Genes

TSPO (Hs), Tspo (Mm), Tspo (Rn)

Ensembl ID

ENSG00000100300 (Hs), ENSMUSG00000041736 (Mm), ENSRNOG00000010549 (Rn)

UniProtKB AC

P30536 (Hs), P50637 (Mm), P16257 (Rn)

Ligands

BAY-069 (Binding) pK_i 7.1 [3] - Rat

Selective ligands

PK 11195 (Binding) pK_i 8.1 [1]

Selective agonists

emapunil [2] - Rat

References

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1. Damont A, Boisgard R, Kuhnast B, Lemée F, Raggiri G, Scarf AM, Da Pozzo E, Selleri S, Martini C, Tavitian B et al.. (2011) Synthesis of 6-[¹⁸F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET. Bioorg Med Chem Lett, 21 (16): 4819-22. [PMID:21741237]

2. Yanamoto K, Kumata K, Yamasaki T, Odawara C, Kawamura K, Yui J, Hatori A, Suzuki K, Zhang MR. (2009) [18F]FEAC and [18F]FEDAC: Two novel positron emission tomography ligands for peripheral-type benzodiazepine receptor in the brain. Bioorg Med Chem Lett, 19 (6): 1707-10. [PMID:19217778]

3. Data for DCP probe BAY-069. Accessed on 21/10/2022. Modified on 21/10/2022. www.ebi.ac.uk/chembl, . DOI: 10.6019/CHEMBL4507325

How to cite this family page

Database page citation:

Mitochondrial-associated proteins. Accessed on 01/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=919.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.