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Target id: 2097
Nomenclature: microtubule affinity regulating kinase 1
Abbreviated Name: MARK1
Family: MARK subfamily
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 795 | 1q41 | MARK1 | microtubule affinity regulating kinase 1 | |
Mouse | - | 795 | 1 H5 | Mark1 | MAP/microtubule affinity regulating kinase 1 | |
Rat | - | 793 | 13q26 | Mark1 | microtubule affinity regulating kinase 1 |
Previous and Unofficial Names ![]() |
Emk3 | Par1c | ELKL motif serine/threonine-protein kinase 3 | MAP/microtubule affinity-regulating kinase 1 |
Database Links ![]() |
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Alphafold | Q9P0L2 (Hs), Q8VHJ5 (Mm), O08678 (Rn) |
BRENDA | 2.7.11.1, 2.7.11.26 |
ChEMBL Target | CHEMBL5940 (Hs) |
Ensembl Gene | ENSG00000116141 (Hs), ENSMUSG00000026620 (Mm), ENSRNOG00000002339 (Rn) |
Entrez Gene | 4139 (Hs), 226778 (Mm), 117016 (Rn) |
Human Protein Atlas | ENSG00000116141 (Hs) |
KEGG Enzyme | 2.7.11.1, 2.7.11.26 |
KEGG Gene | hsa:4139 (Hs), mmu:226778 (Mm), rno:117016 (Rn) |
OMIM | 606511 (Hs) |
Pharos | Q9P0L2 (Hs) |
RefSeq Nucleotide | NM_018650 (Hs), NM_145515 (Mm), NM_053947 (Rn) |
RefSeq Protein | NP_061120 (Hs), NP_663490 (Mm), NP_446399 (Rn) |
UniProtKB | Q9P0L2 (Hs), Q8VHJ5 (Mm), O08678 (Rn) |
Wikipedia | MARK1 (Hs) |
Selected 3D Structures ![]() |
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Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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DiscoveRx KINOMEscan® screen ![]() |
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A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 3,7 |
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Target used in screen: MARK1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen ![]() |
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A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform. http://www.millipore.com/techpublications/tech1/pf3036 http://www.reactionbiology.com/webapps/main/pages/kinase.aspx Reference: 1,4 |
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Target used in screen: MARK1/MARK1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]
2. Busby EC, Leistritz DF, Abraham RT, Karnitz LM, Sarkaria JN. (2000) The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1. Cancer Res, 60 (8): 2108-12. [PMID:10786669]
3. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
4. Gao Y, Davies SP, Augustin M, Woodward A, Patel UA, Kovelman R, Harvey KJ. (2013) A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. Biochem J, 451 (2): 313-28. [PMID:23398362]
5. Moravcevic K, Mendrola JM, Schmitz KR, Wang YH, Slochower D, Janmey PA, Lemmon MA. (2010) Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids. Cell, 143 (6): 966-77. [PMID:21145462]
6. Shi YQ, Sun ZH, Wang ZZ, Su CY, Zhang W, Yu LY, Xu Y, Gao YL, Wang HB, Tian JW et al.. (2023) A novel role for microtubule affinity-regulating kinases in neuropathic pain. Br J Pharmacol, [Epub ahead of print]. [PMID:38112022]
7. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
MARK subfamily: microtubule affinity regulating kinase 1. Last modified on 12/03/2024. Accessed on 20/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2097.