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Target id: 2092
Nomenclature: mitogen-activated protein kinase 6
Abbreviated Name: ERK3
Family: ERK subfamily
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 721 | 15q21.2 | MAPK6 | mitogen-activated protein kinase 6 | |
Mouse | - | 720 | 9 42.3 cM | Mapk6 | mitogen-activated protein kinase 6 | |
Rat | - | 720 | 8q24 | Mapk6 | mitogen-activated protein kinase 6 |
Previous and Unofficial Names ![]() |
MAP kinase 6 | p55-MAPK | p97-MAPK | Prkm4 | PRKM6 | extracellular signal-regulated kinase 3 |
Database Links ![]() |
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Alphafold | Q16659 (Hs), Q61532 (Mm), P27704 (Rn) |
BRENDA | 2.7.11.24 |
ChEMBL Target | CHEMBL5121 (Hs) |
Ensembl Gene | ENSG00000069956 (Hs), ENSMUSG00000042688 (Mm), ENSRNOG00000009381 (Rn) |
Entrez Gene | 5597 (Hs), 50772 (Mm), 58840 (Rn) |
Human Protein Atlas | ENSG00000069956 (Hs) |
KEGG Enzyme | 2.7.11.24 |
KEGG Gene | hsa:5597 (Hs), mmu:50772 (Mm), rno:58840 (Rn) |
OMIM | 602904 (Hs) |
Pharos | Q16659 (Hs) |
RefSeq Nucleotide | NM_002748 (Hs), NM_015806 (Mm), NM_031622 (Rn) |
RefSeq Protein | NP_002739 (Hs), NP_056621 (Mm), NP_113810 (Rn) |
UniProtKB | Q16659 (Hs), Q61532 (Mm), P27704 (Rn) |
Wikipedia | MAPK6 (Hs) |
Selected 3D Structures ![]() |
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Enzyme Reaction ![]() |
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DiscoveRx KINOMEscan® screen ![]() |
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A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1-2 |
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Target used in screen: ERK3 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Displaying the top 10 most potent ligands View all ligands in screen » |
1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
ERK subfamily: mitogen-activated protein kinase 6. Last modified on 19/01/2015. Accessed on 20/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2092.