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Target id: 2066
Nomenclature: mitogen-activated protein kinase kinase 5
Abbreviated Name: MEK5
Family: STE7 family
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 448 | 15q23 | MAP2K5 | mitogen-activated protein kinase kinase 5 | |
Mouse | - | 448 | 9 B-C | Map2k5 | mitogen-activated protein kinase kinase 5 | |
Rat | - | 448 | 8q24 | Map2k5 | mitogen activated protein kinase kinase 5 |
Previous and Unofficial Names ![]() |
dual specificity mitogen-activated protein kinase kinase 5 | MAP kinase kinase 5 | MAPKK5 | PRKMK5 |
Database Links ![]() |
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Alphafold | Q13163 (Hs), Q9WVS7 (Mm), Q62862 (Rn) |
BRENDA | 2.7.12.2 |
ChEMBL Target | CHEMBL4948 (Hs) |
Ensembl Gene | ENSG00000137764 (Hs), ENSMUSG00000058444 (Mm), ENSRNOG00000007926 (Rn) |
Entrez Gene | 5607 (Hs), 23938 (Mm), 29568 (Rn) |
Human Protein Atlas | ENSG00000137764 (Hs) |
KEGG Enzyme | 2.7.12.2 |
KEGG Gene | hsa:5607 (Hs), mmu:23938 (Mm), rno:29568 (Rn) |
OMIM | 602520 (Hs) |
Pharos | Q13163 (Hs) |
RefSeq Nucleotide | NM_001206804 (Hs), NM_011840 (Mm), NM_001033987 (Rn) |
RefSeq Protein | NP_002748 (Hs), NP_035970 (Mm), NP_001029159 (Rn) |
UniProtKB | Q13163 (Hs), Q9WVS7 (Mm), Q62862 (Rn) |
Wikipedia | MAP2K5 (Hs) |
Selected 3D Structures ![]() |
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Enzyme Reaction ![]() |
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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DiscoveRx KINOMEscan® screen ![]() |
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A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform. http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan Reference: 1,3 |
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Target used in screen: MEK5 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | ||
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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]
2. Tatake RJ, O'Neill MM, Kennedy CA, Wayne AL, Jakes S, Wu D, Kugler Jr SZ, Kashem MA, Kaplita P, Snow RJ. (2008) Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem Biophys Res Commun, 377 (1): 120-5. [PMID:18834865]
3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]
STE7 family: mitogen-activated protein kinase kinase 5. Last modified on 09/11/2016. Accessed on 20/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2066.