Contents:
- Gene and Protein Information
- Previous and Unofficial Names
- Database Links
- Associated Proteins
- Functional Characteristics
- Ion Selectivity and Conductance
- Activators
- Tissue Distribution
- Physiological Functions
- Phenotypes, Alleles and Disease Models
- Clinically-Relevant Mutations and Pathophysiology
- References
- Contributors
- How to cite this page
Gene and Protein Information  |
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| Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 2 | 1 | 393 | 1q23.2 | KCNJ9 | potassium inwardly rectifying channel subfamily J member 9 | 20 |
| Mouse | 2 | 1 | 393 | 1 79.66 cM | Kcnj9 | potassium inwardly-rectifying channel, subfamily J, member 9 | 13,19,29 |
| Rat | 2 | 1 | 393 | 13q24 | Kcnj9 | potassium inwardly-rectifying channel, subfamily J, member 9 | 6,28 |
| Previous and Unofficial Names |
| potassium inwardly rectifying channel subfamily J member 9 | GIRK3 | G protein-activated inward rectifier potassium channel 3 | inward rectifier K(+) channel Kir3.3 | potassium channel, inwardly rectifying subfamily J, member 9 | potassium inwardly-rectifying channel | potassium voltage-gated channel subfamily J member 9 |
| Database Links |
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| Alphafold | Q92806 (Hs), P48543 (Mm), Q63511 (Rn) |
| CATH/Gene3D | 2.60.40.1400 |
| ChEMBL Target | CHEMBL3038490 (Hs) |
| Ensembl Gene | ENSG00000162728 (Hs), ENSMUSG00000038026 (Mm), ENSRNOG00000007645 (Rn) |
| Entrez Gene | 3765 (Hs), 16524 (Mm), 116560 (Rn) |
| Human Protein Atlas | ENSG00000162728 (Hs) |
| KEGG Gene | hsa:3765 (Hs), mmu:16524 (Mm), rno:116560 (Rn) |
| OMIM | 600932 (Hs) |
| Pharos | Q92806 (Hs) |
| RefSeq Nucleotide | NM_004983 (Hs), NM_008429 (Mm), NM_053834 (Rn) |
| RefSeq Protein | NP_004974 (Hs), NP_032455 (Mm), NP_446286 (Rn) |
| UniProtKB | Q92806 (Hs), P48543 (Mm), Q63511 (Rn) |
| Wikipedia | KCNJ9 (Hs) |
| Associated Proteins |
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| Associated Protein Comments | ||||||||||||||||||||||||
Trafficking and expression:
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| Functional Characteristics |
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| G protein-activated inward-rectifier current | |
| Ion Selectivity and Conductance |
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| Ion Selectivity and Conductance Comments | ||||||
| Kir3.3 forms functional heteromers with Kir3.2 (31pS, [10]) and Kir3.1 (39pS, [11,14]). |
Download all structure-activity data for this target as a CSV file 
| Activators | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Activator Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kir3.3 in complex with Kir3.1 is activated by Gβγ subunits (pEC50 = 11 [11]). | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tissue Distribution
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| Physiological Functions
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| Physiological Functions Comments | ||||||||
| For review see [22]. | ||||||||
| Phenotypes, Alleles and Disease Models
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Mouse data from MGI | ||||||||||||||||||||||||||||||
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| Clinically-Relevant Mutations and Pathophysiology
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References
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2. Balana B, Bahima L, Bodhinathan K, Taura JJ, Taylor NM, Nettleton MY, Ciruela F, Slesinger PA. (2013) Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels. PLoS ONE, 8 (3): e59800. [PMID:23536889]
3. Balana B, Maslennikov I, Kwiatkowski W, Stern KM, Bahima L, Choe S, Slesinger PA. (2011) Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27. Proc Natl Acad Sci USA, 108 (14): 5831-6. [PMID:21422294]
4. Ciruela F, Fernández-Dueñas V, Sahlholm K, Fernández-Alacid L, Nicolau JC, Watanabe M, Luján R. (2010) Evidence for oligomerization between GABAB receptors and GIRK channels containing the GIRK1 and GIRK3 subunits. Eur J Neurosci, 32 (8): 1265-77. [PMID:20846323]
5. Cruz HG, Ivanova T, Lunn ML, Stoffel M, Slesinger PA, Lüscher C. (2004) Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine system. Nat Neurosci, 7 (2): 153-9. [PMID:14745451]
6. Dissmann E, Wischmeyer E, Spauschus A, Pfeil DV, Karschin C, Karschin A. (1996) Functional expression and cellular mRNA localization of a G protein-activated K+ inward rectifier isolated from rat brain. Biochem Biophys Res Commun, 223 (2): 474-9. [PMID:8670306]
7. Fernández-Alacid L, Aguado C, Ciruela F, Martín R, Colón J, Cabañero MJ, Gassmann M, Watanabe M, Shigemoto R, Wickman K et al.. (2009) Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells. J Neurochem, 110 (4): 1363-76. [PMID:19558451]
8. Fowler CE, Aryal P, Suen KF, Slesinger PA. (2007) Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. J Physiol (Lond.), 580 (Pt 1): 51-65. [PMID:17185339]
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12. Karschin C, Karschin A. (1997) Ontogeny of gene expression of Kir channel subunits in the rat. Mol Cell Neurosci, 10 (3-4): 131-48. [PMID:9532576]
13. Kobayashi T, Ikeda K, Ichikawa T, Abe S, Togashi S, Kumanishi T. (1995) Molecular cloning of a mouse G-protein-activated K+ channel (mGIRK1) and distinct distributions of three GIRK (GIRK1, 2 and 3) mRNAs in mouse brain. Biochem Biophys Res Commun, 208 (3): 1166-73. [PMID:7702616]
14. Kofuji P, Davidson N, Lester HA. (1995) Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers. Proc Natl Acad Sci USA, 92 (14): 6542-6. [PMID:7604029]
15. Koyrakh L, Luján R, Colón J, Karschin C, Kurachi Y, Karschin A, Wickman K. (2005) Molecular and cellular diversity of neuronal G-protein-gated potassium channels. J Neurosci, 25 (49): 11468-78. [PMID:16339040]
16. Kozell LB, Walter NA, Milner LC, Wickman K, Buck KJ. (2009) Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol. J Neurosci, 29 (37): 11662-73. [PMID:19759313]
17. Labouèbe G, Lomazzi M, Cruz HG, Creton C, Luján R, Li M, Yanagawa Y, Obata K, Watanabe M, Wickman K et al.. (2007) RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area. Nat Neurosci, 10 (12): 1559-68. [PMID:17965710]
18. Lalive AL, Munoz MB, Bellone C, Slesinger PA, Lüscher C, Tan KR. (2014) Firing modes of dopamine neurons drive bidirectional GIRK channel plasticity. J Neurosci, 34 (15): 5107-14. [PMID:24719090]
19. Lesage F, Duprat F, Fink M, Guillemare E, Coppola T, Lazdunski M, Hugnot JP. (1994) Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain. FEBS Lett, 353 (1): 37-42. [PMID:7926018]
20. Lesage F, Fink M, Barhanin J, Lazdunski M, Mattéi MG. (1995) Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23. Genomics, 29 (3): 808-9. [PMID:8575783]
21. Lunn ML, Nassirpour R, Arrabit C, Tan J, McLeod I, Arias CM, Sawchenko PE, Yates 3rd JR, Slesinger PA. (2007) A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction. Nat Neurosci, 10 (10): 1249-59. [PMID:17828261]
22. Lüscher C, Slesinger PA. (2010) Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease. Nat Rev Neurosci, 11 (5): 301-15. [PMID:20389305]
23. Ma D, Zerangue N, Raab-Graham K, Fried SR, Jan YN, Jan LY. (2002) Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart. Neuron, 33 (5): 715-29. [PMID:11879649]
24. Morgan AD, Carroll ME, Loth AK, Stoffel M, Wickman K. (2003) Decreased cocaine self-administration in Kir3 potassium channel subunit knockout mice. Neuropsychopharmacology, 28 (5): 932-8. [PMID:12637950]
25. Munoz MB, Slesinger PA. (2014) Sorting nexin 27 regulation of G protein-gated inwardly rectifying K⁺ channels attenuates in vivo cocaine response. Neuron, 82 (3): 659-69. [PMID:24811384]
26. Pravetoni M, Wickman K. (2008) Behavioral characterization of mice lacking GIRK/Kir3 channel subunits. Genes Brain Behav, 7 (5): 523-31. [PMID:18194467]
27. Torrecilla M, Marker CL, Cintora SC, Stoffel M, Williams JT, Wickman K. (2002) G-protein-gated potassium channels containing Kir3.2 and Kir3.3 subunits mediate the acute inhibitory effects of opioids on locus ceruleus neurons. J Neurosci, 22 (11): 4328-34. [PMID:12040038]
28. Vaughn J, Wolford JK, Prochazka M, Permana PA. (2000) Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3). Biochem Biophys Res Commun, 274 (2): 302-9. [PMID:10913335]
29. Wickman K, Pu WT, Clapham DE. (2002) Structural characterization of the mouse Girk genes. Gene, 284 (1-2): 241-50. [PMID:11891065]
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