Synonyms: Rob-803 | Rob803
Compound class:
Synthetic organic
Comment: Rabeximod is an orally active immunomodulator. It has potent anti-rheumatic effects in animal models and is being evaluated as a potential drug for rheumatoid arthritis patients. The structure was originally claimed in patent WO2005123741A1 (Compound E) for anti-inflammatory potential [1], and later for antiviral potential in patent WO2014140321A1 (example 2). The molecular mechanism of action of this compound vis its anti-inflammatory activity remains unclear.
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References |
1. Bergman J, Engqvist R, Gerdin B, Kihlström I, Björklumd U. (2005)
Alkyl substituted indoloquinoxalines. Patent number: WO2005123741. Assignee: Oxypharma Ab. Priority date: 17/06/2004. Publication date: 29/12/2005. |
2. Giusti P, Frascaroli G, Tammik C, Gredmark-Russ S, Söderberg-Nauclér C, Varani S. (2011)
The novel anti-rheumatic compound Rabeximod impairs differentiation and function of human pro-inflammatory dendritic cells and macrophages. Immunobiology, 216 (1-2): 243-50. [PMID:20494473] |
3. Westman E, Thi Ngoc DD, Klareskog L, Harris HE. (2008)
Suppressive effects of a quinoxaline-analogue (Rob 803) on pathogenic immune mechanisms in collagen-induced arthritis. Clin Exp Immunol, 152 (1): 192-9. [PMID:18307516] |