Synonyms: Rob-803 | Rob803
Compound class:
Synthetic organic
Comment: Rabeximod is an orally active immunomodulator. It has potent anti-rheumatic effects in animal models and is being evaluated as a potential drug for rheumatoid arthritis patients. The structure was originally claimed in patent WO2005123741A1 (Compound E) for anti-inflammatory potential [1], and later for antiviral potential in patent WO2014140321A1 (example 2). The molecular mechanism of action of this compound vis its anti-inflammatory activity remains unclear.
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Immunopharmacology Comments |
Rabeximod (Rob 803) exhibits anti-rheumatic efficacy in in vitro arthritis models [3]. It appears to act early in monocyte differentiation, to inhibit monocyte differentiation to pro-inflammatory professional antigen presenting cells, as well attenuating the immunostimulatory capacity of these cells [2]. Its molecular target has yet to be defined. |
Immunopharmacology Disease | |||
Disease | X-Refs | Comment | References |
Rheumatoid arthritis |
Disease Ontology:
DOID:7148 OMIM: 180300 |
Phase 2 evaluation as an adjunct to methotrexate therapy in RA has been completed- see NCT00525213 |