ICOS ligand

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Ligands
ICOS ligand (Human)

GtoPdb Ligand ID: 9593

Abbreviated name: CD275

Synonyms: B7 homolog 2 | B7-H2 | B7-related protein 1 | B7RP-1 | ICOS-L

Compound class: Endogenous peptide in human, mouse or rat

Comment: Endogenous ligand for ICOS [1] that is expressed on the surface of antigen presenting cells. Inhibiting the ICOS/ICOSL axis is predicted to provide anti-inflammatory activity applicable for the treatment of autoimmune diseases.
The ICOSL protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590.
The anti-ICOSL monoclonal antibody MEDI5872 (AMG557) is being evaluated in Phase 2 clinical trial in patients with primary Sjögren's syndrome (NCT02334306). Phase 1 trials of the same biologic in systemic lupus erythematosus (SLE) and psoriasis were terminated.

Species: Human

References
1. Yoshinaga SK, Zhang M, Pistillo J, Horan T, Khare SD, Miner K, Sonnenberg M, Boone T, Brankow D, Dai T et al.. (2000) Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS. Int Immunol, 12 (10): 1439-47. [PMID:11007762]

References

1. Yoshinaga SK, Zhang M, Pistillo J, Horan T, Khare SD, Miner K, Sonnenberg M, Boone T, Brankow D, Dai T et al.. (2000)
Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS.
Int Immunol, 12 (10): 1439-47. [PMID:11007762]