Synonyms: compound 29 [PMID: 25101488]
Compound class:
Synthetic organic
Comment: BMS-817399 is a selective and orally bioavailable CCR1 receptor antagonist [1].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Immunopharmacology Comments |
CCR1 is implicated in maintaining the population of inflammatory cells within the synovial tissues and fluid of joints in human RA patients. Functional potency of BMS-817399 in preclinical assessments failed to translate to efficacy in human trial participants with RA. |
Immunopharmacology Disease | |||
Disease | X-Refs | Comment | References |
Rheumatoid arthritis |
Disease Ontology:
DOID:7148 OMIM: 180300 |
BMS-817399 was a clinical candidate for RA that reached Phase 2 clinical trial |