Compound class:
Synthetic organic
Comment: TG6-129 is a selective prostanoid EP2 receptor antagonist probe [1]. As it does not the blood brain barrier it is a useful tool for investigating peripheral anti-inflammatory mechanisms of EP2 antagonism. Peripherally acting EP2 antagonists are being investigated for clinical potential in chronic inflammatory diseases such as rheumatoid arthritis and chronic obstructive pulmonary disease (COPD).
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
References |
1. Ganesh T, Jiang J, Shashidharamurthy R, Dingledine R. (2013)
Discovery and characterization of carbamothioylacrylamides as EP2 selective antagonists. ACS Med Chem Lett, 4 (7): 616-621. [PMID:23914286] |