SC-67655   Click here for help

GtoPdb Ligand ID: 8889

Immunopharmacology Ligand
Compound class: Peptide
Comment: SC-67655 is a pentapeptide designed as an immunomodulatory agent with potential to treat rheumatiod arthritis [1].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
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Mechanism Of Action and Pharmacodynamic Effects Click here for help
SC-67655 binds to the MHC Class II cell surface molecule DR4, which is clinically associated with rheumatoid arthritis (RA). This interaction prevents presentation of RA associated disease-inducing peptide antigens to autoreactive T-cells [1].