Abbreviated name: TSA
Compound class:
Synthetic organic
Comment: Trichostatin A Inhibits Class I and II histone deacetylases (HDACs), but NOT the Class III HDACs (sirtuins (SIRTs) 1-7), so is therefore a useful probe of histone deacetylase activity. HDAC1 has been tagged as the drug's primary target for data retrieval purposes only and in no way infers that this is the only target of this drug.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide |
Database Links | |
CAS Registry No. | 58880-19-6 |
ChEMBL Ligand | CHEMBL99 |
DrugBank Ligand | DB04297 |
GtoPdb PubChem SID | 178103584 |
LIPID MAPS | LMPK01000055 |
PubChem CID | 444732 |
RCSB PDB Ligand | TSN |
Search Google for chemical match using the InChIKey | RTKIYFITIVXBLE-QEQCGCAPSA-N |
Search Google for chemicals with the same backbone | RTKIYFITIVXBLE |
SynPHARM |
79159 (in complex with histone deacetylase 6) 79163 (in complex with histone deacetylase 8) |
UniChem Compound Search for chemical match using the InChIKey | RTKIYFITIVXBLE-QEQCGCAPSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | RTKIYFITIVXBLE-QEQCGCAPSA-N |
Wikipedia | Trichostatin_A |
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Trichostatin A (links to external site)
Cat. No. 1406 |