Synonyms: L04AA02 | OKT-3 | Orthoclone Okt3®
muromonab-CD3 is an approved drug (FDA (1992))
Compound class:
Antibody
Comment: Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
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Immunopharmacology Comments |
Muromonab-CD3 binds to CD3 on T cells and induces Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity. |
Immunopharmacology Disease | |||
Disease | X-Refs | Comment | References |
Allograft rejection | Approved to prevent renal, cardiac and hepatic allograft rejection. Withdrawn from the US market. |