GSK690693   Click here for help

GtoPdb Ligand ID: 5196

Synonyms: compound 3g [PMID 18800763] | GSK 690693 | GSK-690693
PDB Ligand
Compound class: Synthetic organic
Comment: GSK-690693 is an ATP competitive, pan-AKT kinase inhibitor [2-3].
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species
2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 137.14
Molecular weight 425.22
XLogP 1.99
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

✖
Canonical SMILES CCn1c(nc2c1c(OCC1CCCNC1)cnc2C#CC(O)(C)C)c1nonc1N
Isomeric SMILES CCn1c(nc2c1c(OC[C@H]1CCCNC1)cnc2C#CC(O)(C)C)c1nonc1N
InChI InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1
InChI Key KGPGFQWBCSZGEL-ZDUSSCGKSA-N
Bioactivity Comments
GSK-690693 inhibits other AGC family kinases due to their shared ATP domain structure (eg MSK1, ROCK1, and RSK, and to a lesser extent PKA, PrkX, and PKC isozymes) [2]. CAMK family kinases AMPK and DAPK3 and STE family kinases PAK4, 5, and 6 are also inhibited by GSK-690693 [2]. See Table 5 in Heerding et al (2008) [2] for IC50s for all kinases screened for GSK-690693 inhibition.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
AKT serine/threonine kinase 1 Primary target of this compound Hs Inhibitor Inhibition 8.7 pKd - 1
⤷ pKd 8.7 (Kd 2.2x10-9 M) [1]
protein kinase, cAMP-dependent, catalytic, beta subunit Hs Inhibitor Inhibition 7.9 pKd - 1
⤷ pKd 7.9 (Kd 1.3x10-8 M) [1]
protein kinase, cAMP-dependent, catalytic, alpha subunit Hs Inhibitor Inhibition 7.7 pKd - 1
⤷ pKd 7.7 (Kd 1.9x10-8 M) [1]
large tumor suppressor kinase 2 Hs Inhibitor Inhibition 6.8 pKd - 1
⤷ pKd 6.8 (Kd 1.4x10-7 M) [1]
AKT serine/threonine kinase 1 Primary target of this compound Hs Inhibitor Inhibition 8.7 pIC50 - 2
⤷ pIC50 8.7 (IC50 2x10-9 M) [2]
protein kinase C theta Hs Inhibitor Inhibition 8.7 pIC50 - 2
⤷ pIC50 8.7 (IC50 2x10-9 M) [2]
protein kinase X-linked Hs Inhibitor Inhibition 8.3 pIC50 - 2
⤷ pIC50 8.3 (IC50 5x10-9 M) [2]
p21 (RAC1) activated kinase 6 Hs Inhibitor Inhibition 8.2 pIC50 - 2
⤷ pIC50 8.2 (IC50 6x10-9 M) [2]
Description: Data from binding assays.
AKT serine/threonine kinase 3 Primary target of this compound Hs Inhibitor Inhibition 8.1 pIC50 - 2
⤷ pIC50 8.1 (IC50 9x10-9 M) [2]
p21 (RAC1) activated kinase 4 Hs Inhibitor Inhibition 8.0 pIC50 - 2
⤷ pIC50 8.0 (IC50 1x10-8 M) [2]
Description: Data from binding assays.
AKT serine/threonine kinase 2 Primary target of this compound Hs Inhibitor Inhibition 7.9 pIC50 - 2
⤷ pIC50 7.9 (IC50 1.3x10-8 M) [2]
Protein kinase G (PKG) 1 Hs Inhibitor Inhibition 7.5 pIC50 - 2
⤷ pIC50 7.5 (IC50 3.3x10-8 M) [2]
p21 (RAC1) activated kinase 5 Hs Inhibitor Inhibition 7.3 pIC50 - 2
⤷ pIC50 7.3 (IC50 5.2x10-8 M) [2]