clofibrate   Click here for help

GtoPdb Ligand ID: 2667

Synonyms: Atromid-S® | AY-61123 | ICI-28257
Approved drug
clofibrate is an approved drug (FDA (1967))
Compound class: Synthetic organic
Comment: The marketing of many formulations of clifobrate has been discontinued
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: clofibrate

clofibrate is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 35.53
Molecular weight 242.07
XLogP 3.32
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCOC(=O)C(Oc1ccc(cc1)Cl)(C)C
Isomeric SMILES CCOC(=O)C(Oc1ccc(cc1)Cl)(C)C
InChI InChI=1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
InChI Key KNHUKKLJHYUCFP-UHFFFAOYSA-N
No information available.
Summary of Clinical Use Click here for help
Clofibrate is an antilipidemic agent. It acts to lower elevated serum lipids and may therfore be used to treat conditions causing high cholesterol and high triglyceride levels, such as hyperlipoproteinemia type III and severe hypertriglyceridemia.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Clofibrate is a peroxisome proliferator-activated receptor alpha (PPARA) agonist in muscle, liver, and other tissues, activation of which leads to altered gene expression resulting in increased beta-oxidation, decreased triglyceride secretion, increased HDL and increased lipoprotein lipase activity.