mefenamic acid   Click here for help

GtoPdb Ligand ID: 2593

Synonyms: CI-473 | CN-35355 | INF-3355 | Ponstan® | Ponstel®
Approved drug PDB Ligand Immunopharmacology Ligand
mefenamic acid is an approved drug (FDA (1967))
Compound class: Synthetic organic
Comment: Mefenamic acid is an anthranilic acid derivative (or fenamate) class NSAID drug.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 49.33
Molecular weight 241.11
XLogP 3.94
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES OC(=O)c1ccccc1Nc1cccc(c1C)C
Isomeric SMILES OC(=O)c1ccccc1Nc1cccc(c1C)C
InChI InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18)
InChI Key HYYBABOKPJLUIN-UHFFFAOYSA-N
No information available.
Summary of Clinical Use Click here for help
Used in the treatment of rheumatoid arthritis, osteoarthritis, dysmenorrhea, inflammation, fever and pain.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Mefenamic acid inhibits prostaglandin synthetase thereby interfering with the mediation of inflammation and pain.