Synonyms: 16α-OHE1 | 16-hydroxyestrone | 16alpha-hydroxyestrone | 16alpha-OHE1
Compound class:
Synthetic organic
Comment: 16α-hydroxyestrone is an estrogenic metabolite that is a 16-hydroxylation product generated during the catalytic breakdown of estrone by cytochrome P450 enzymes in the liver (principally CYP3A4 and 3A5).
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
16α-hydroxyestrone interacts with estrogen receptors [5], has uterotrophic effects and decreases circulating luteinizing hormone concentrations in rats [1,3]. Overproduction of 16α-hydroxyestrone has been implicated in the pathophysiology of breast cancer [2,4]. |
Selectivity at nuclear hormone receptors | ||||||||||||||||||||||||||||||||||
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