Synonyms: compound 61 [WO2014015056A2]
Compound class:
Synthetic organic
Comment: This compound was claimed as a MAPK13 (p38δ) inhibitor in patent WO2014015056A2 [3]. MAPK13-IN-1 was proposed for mucous-reducing activity with application in respiratory diseases like asthma and COPD. It was designed to act by reducing MAPK13 signalling-induced mucous production by airway epithelial cells in response to activation by the pro-inflammatory cytokine, IL-13 [1]. MAPK13-IN-1 binds to MAPK13 in DFG-out mode and exhibits slow dissociation kinetics.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
1-(5-tert-butyl-2-methylpyrazol-3-yl)-3-(4-pyridin-4-yloxyphenyl)urea |
Synonyms ![]() |
compound 61 [WO2014015056A2] |
Database Links ![]() |
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BindingDB Ligand | 50249406 |
ChEMBL Ligand | CHEMBL472620 |
GtoPdb PubChem SID | 434122157 |
PubChem CID | 17941505 |
RCSB PDB Ligand | N61 |
Search Google for chemical match using the InChIKey | MHSLDASSAFCCDO-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | MHSLDASSAFCCDO |
UniChem Compound Search for chemical match using the InChIKey | MHSLDASSAFCCDO-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | MHSLDASSAFCCDO-UHFFFAOYSA-N |