rosiglitazone   Click here for help

GtoPdb Ligand ID: 1056

Synonyms: Avandia® | rosiglizole
Approved drug
rosiglitazone is an approved drug (FDA (1999), EMA (2000))
Compound class: Synthetic organic
Comment: Marketed formulations may contain rosiglitazone maleate (PubChem CID 5281055).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: rosiglitazone

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 96.83
Molecular weight 357.11
XLogP 2.44
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C
Isomeric SMILES O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C
InChI InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23)
InChI Key YASAKCUCGLMORW-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1999), EMA (2000))
Withdrawn drug? Yes
IUPAC Name Click here for help
5-[[4-[2-(methyl-pyridin-2-ylamino)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
International Nonproprietary Names Click here for help
INN number INN
7662 rosiglitazone
Synonyms Click here for help
Avandia® | rosiglizole
Database Links Click here for help
Specialist databases
GPCRdb Ligand rosiglitazone
Other databases
BindingDB Ligand 28681
CAS Registry No. 122320-73-4 (source: ChEBI)
ChEBI CHEBI:50122
ChEMBL Ligand CHEMBL121
DrugBank Ligand DB00412
DrugCentral Ligand 2405
GtoPdb PubChem SID 135650927
PubChem CID 77999
Search Google for chemical match using the InChIKey YASAKCUCGLMORW-UHFFFAOYSA-N
Search Google for chemicals with the same backbone YASAKCUCGLMORW
Search PubMed clinical trials rosiglitazone
Search PubMed titles rosiglitazone
Search PubMed titles/abstracts rosiglitazone
SynPHARM 79481 (in complex with Peroxisome proliferator-activated receptor-γ)
6357 (in complex with Peroxisome proliferator-activated receptor-γ)
UniChem Compound Search for chemical match using the InChIKey YASAKCUCGLMORW-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey YASAKCUCGLMORW-UHFFFAOYSA-N
Wikipedia Rosiglitazone

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Tocris
Rosiglitazone (links to external site)
Cat. No. 5325