Synonyms: compound 3 [PMID: 31265286] | Example 1 [WO2014043446A1] | GSK2983559
Compound class:
Synthetic organic
Comment: This is an orally active RIPK2 inhibitor phosphate ester prodrug [1-2]. It is rapidly cleaved by alkaline phosphatases on contact with intestinal tissue and in whole blood. The prodrug formulation was designed to limit systemic exposure, and to focus activity at the preferred site of action in gut tissue.
A crystal structure of RIPK2 in complex with inhibitor 3 has been submitted to the PDB with ID 6RN8. |
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Classification | |
Compound class | Synthetic organic |
Is prodrug? | Yes |
Active form | RIPK2 inhibitor 5 |
IUPAC Name |
2-[4-(1,3-benzothiazol-5-ylamino)-6-tert-butylsulfonylquinazolin-7-yl]oxyethyl dihydrogen phosphate |
Synonyms |
compound 3 [PMID: 31265286] | Example 1 [WO2014043446A1] | GSK2983559 |
Database Links | |
GtoPdb PubChem SID | 385612173 |
PubChem CID | 73386708 |
RCSB PDB Ligand | K9T |
Search Google for chemical match using the InChIKey | MJLYDVMFNHZMLV-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | MJLYDVMFNHZMLV |
UniChem Compound Search for chemical match using the InChIKey | MJLYDVMFNHZMLV-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | MJLYDVMFNHZMLV-UHFFFAOYSA-N |